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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/34708
Title: 
Dissociation and electrooxidation of primaquine diphosphate as an approach to the study of anti-chagas prodrugs mechanism of action
Author(s): 
Institution: 
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
  • Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
ISSN: 
0302-4598
Abstract: 
This paper describes the voltammetric behavior of primaquine as a previous support to the further understanding of the delivery and action mechanisms of its respective synthesized prodrugs. There are few papers describing the drug behavior and most of the time no correlation between oxidation process and pH is done. Our results showed that primaquine oxidation is a one-step reaction involving two electrons with the charge transfer process being strongly pH-dependent in acid medium and pH-independent in a weak basic medium, with the neutral form being easily oxidized.This leads to the conclusion that quinoline nitrogen ring neutralization is a determinant step to the formation of the oxidized primaquine form. The existence of a relationship between the primaquine dissociation equilibrium and its electrooxidation process is shown.This work points the importance of voltammetric methodology as a tool for further studies on quantitative relationship studies between chemical structure and biological activity (QSAR) for electroactive drugs. (C) 2000 Elsevier B.V. S.A. All rights reserved.
Issue Date: 
1-Jan-2001
Citation: 
Bioelectrochemistry. Lausanne: Elsevier B.V. Sa, v. 53, n. 1, p. 55-59, 2001.
Time Duration: 
55-59
Publisher: 
Elsevier B.V.
Keywords: 
  • primaquine
  • electrooxidation
  • proton dissociation
Source: 
http://dx.doi.org/10.1016/S0302-4598(00)00093-3
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/34708
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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