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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/35535
Título: 
THE BEHAVIORAL SENSITIZATION INDUCED BY FENCAMFAMINE IS NOT RELATED TO PLASMA DRUG LEVELS
Autor(es): 
Instituição: 
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
ISSN: 
0100-879X
Resumo: 
Fencamfamine (FCF) is a CNS stimulant that facilitates central dopaminergic transmission primarily through blockade of dopamine uptake. In the present study we evaluated the relationship between plasma FCF concentration and behavioral sensitization effect. Adult male Wistar rats (250-300 g) received FCF (10 mg/kg, kg, ip) or saline once or daily for 10 consecutive days (N = 10 for each group). Blood samples were collected 30 min after injections and plasma FCF was measured by gas chromatography using an electron capture detector. FCF treatment enhanced sniffing duration (16.8 +/- 0.8 vs 26.6 +/- 0.9 s) and decreased rearing behavior (8.2 +/- 0.8 vs 3.7 +/- 0.6 s) when days 1 and 10 of drug administration were compared. Comparison of pair of means by the Student t-test did not show significant differences in plasma FCF concentration (390 +/- 40 vs 420 +/- 11 ng/ml) when blood samples were collected 30 min after acute FCF administration or after daily administration of 10 mg/kg for 10 days. In conclusion, the behavioral sensitization to FCF could not be correlated with plasma drug levels, and changes in the activity of dopaminergic systems should be considered to explain the sensitization to the effect of FCF.
Data de publicação: 
1-Jun-1995
Citação: 
Brazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 28, n. 6, p. 667-670, 1995.
Duração: 
667-670
Publicador: 
Associação Brasileira de Divulgação Científica (ABRADIC)
Palavras-chaves: 
  • FENCAMFAMINE
  • PLASMA FENCAMFAMINE LEVELS
  • BEHAVIORAL SENSITIZATION
  • DOPAMINERGIC SYSTEMS
Fonte: 
http://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/35535
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