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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/37047
Título: 
Commissural NTS contributes to pressor responses to glutamate injected into the medial NTS of awake rats
Autor(es): 
Instituição: 
  • UNIV IOWA
  • VET AFFAIRS MED CTR
  • Universidade Estadual Paulista (UNESP)
ISSN: 
0363-6119
Resumo: 
In the present study we investigated whether interruption of the chemoreceptor reflex by an electrolytic lesion of the commissural subnucleus of the nucleus tractus solitarii (commNTS) influenced presser and bradycardic responses induced by microinjection of L-glutamate (L-Glu) into the medial NTS (mNTS) of conscious rats. Seven days after sham lesions, seven rats demonstrated significant presser [change in mean arterial pressure (MAP) = +33 +/- 3 mmHg] and bradycardic [change in heart rate (HR) = -74 +/- 8 beats/min (bpm)] responses to chemoreceptor reflex activation by intravenous injection of KCN. Likewise, L-Glu (1 nmol in 100 nl) injected into the mNTS in sham rats induced presser (+29 +/- 2 mmHg) and bradycardic responses (-90 +/- 8 bpm). However, in 11 rats with lesions in commNTS, presser and bradycardic chemoreceptor reflex responses were abolished, and injection of L-Glu into the mNTS decreased MAP (-14 +/- 6 mmHg) and HR (-59 +/- 16 bpm) as is reported in anesthetized control rats. We conclude that presser responses induced by L-Glu microinjected into the baroreceptor reflex region of mNTS in conscious rats depend on the integrity of the commNTS, which plays an important role in central chemoreceptor reflex pathways.
Data de publicação: 
1-Jun-1996
Citação: 
American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 270, n. 6, p. R1220-R1225, 1996.
Duração: 
R1220-R1225
Publicador: 
Amer Physiological Soc
Palavras-chaves: 
  • arterial pressure
  • baroreceptor
  • chemoreceptor
  • excitatory amino acids
  • KCN
  • medulla
  • nucleus tractus solitarii
Fonte: 
http://ajpregu.physiology.org/content/270/6/R1220
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/37047
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