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- Electrochemical oxidation and voltammetric determination of the antimalaria drug primaquine
- Universidade Estadual Paulista (UNESP)
- Universidade Federal de Santa Catarina (UFSC)
- Primaquine, an antimalarial drug, presents a well-defined oxidation peak around +0.6V vs SCE at a glassy carbon electrode that can be used for its determination. Calibration graphs were obtained for primaquine in B-R buffer pH 4.0 from 3.00 x 10(-5) mol L-1 to 1.00 x 10(-2) mol L-1 using linear-scan voltammetry and 3.00 x 10(-5) mol L-1 to 1.00 x 10(-2) mol L-1 using differential pulse or square-wave voltammetry. The correspondent detection limits was 9.4 mu g mL(-1); 4.2 and 1.8 mu g mL(-1), respectively. All the voltammetric methods were applied with success in direct determination of the primaquine in commercial tablets without separation or extraction procedures.
- Analytical Letters. Philadelphia: Taylor & Francis Inc., v. 38, n. 9, p. 1415-1425, 2005.
- Taylor & Francis Inc
- cyclic voltammetry
- differential-pulse voltammetry
- square-wave voltammetry
- Acesso restrito
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