Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/40834
- Title:
- Drug-matrix interaction of sodium diclofenac incorporated into ureasilpoly(ethylene oxide) hybrid materials
- Universidade Estadual Paulista (UNESP)
- Synchrotron SOLEIL
- 2046-2069
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- Centre national de la recherche scientifique (CNRS)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- The objective of this work was to study the interactions between a model drug, sodium diclofenac (SDCF), and ureasil-poly(ethylene oxide) (PEO) hybrid materials, aiming to understand and to optimize the drug delivery behaviour. Ureasil-PEO hybrids obtained by the sol-gel process and containing short (PEO500) and long (PEO1900) polymer chains were prepared. Differential scanning calorimetry (DSC), Raman spectroscopy and Si-29 NMR were used to investigate the interactions between SDCF and the hybrid matrix. The decrease in melting temperature of the semi-crystalline PEO1900 hybrid from 30.1 (SDCF-free matrix) to 22.3 degrees C (SDCF-loaded matrix) and the decrease of the T-g values of about -3 degrees C in SDCF-loaded PEO500 matrices associated to the Raman results confirm the interactions between SDCF and the PEO chains of the hybrid matrix. The role of the coexistence of crystalline and amorphous hybrid phase was clearly evinced by the bimodal drug release pattern achieved for the PEO1900 matrix.
- 1-Jan-2012
- Rsc Advances. Cambridge: Royal Soc Chemistry, v. 2, n. 13, p. 5629-5636, 2012.
- 5629-5636
- Royal Soc Chemistry
- http://dx.doi.org/10.1039/c2ra01216b
- Acesso restrito
- outro
- http://repositorio.unesp.br/handle/11449/40834
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.