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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/42135
Título: 
Liposomal encapsulation improves the duration of soft tissue anesthesia but does not induce pulpal anesthesia
Autor(es): 
Instituição: 
  • Universidade Estadual de Campinas (UNICAMP)
  • Universidade Estadual Paulista (UNESP)
ISSN: 
0952-8180
Financiador: 
  • DFL Ind Corn Ltda, Rio de Janeiro, Brazil
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Resumo: 
Study Objective: To compare the topical and the pulpal anesthesia efficacy of liposomal and plain benzocaine formulationsDesign: Double-blinded, randomized crossover study.Setting: University ambulatory dental centerPatients: 30 ASA physical status 1 volunteersInterventions: Volunteers received, in three different sessions, topical application of liposome-encapsulated 10% benzocaine (LB10), 10% benzocaine gel (B10), and 20% benzocaine gel (B20) in the right maxillary canine mucobuccal foldMeasurements: Pain associated with the needle insertion was rated by visual analog scale (VAS) and the duration of topical anesthesia was recorded Pulpal anesthesia was evaluated using an electric pulp testerMain Results: VAS values (median. 1st - 3rd quartiles) were 17 cm (11 - 25), 14 cm (3 - 22), and 21 cm (9 21) for B10, LB10, and 1320, respectively No differences were noted among the groups (Friedman test, P = 0 58) Soft tissue anesthesia was also not different The LB10 [10 (8 - 12) min] showed longer soft tissue anesthesia (Friedman test, P < 0 01) than the other agents [1310 = 8 (5 - 10) min, and B20 = 7 (6 - 9) min] None of the topical benzocaine formulations tested induced pulpal anesthesiaConclusions: The encapsulation of benzocaine into liposome increased the duration of soft tissue anesthesia However, it did not induce pulpal anesthesia (C) 2010 Elsevier Inc All rights reserved
Data de publicação: 
1-Ago-2010
Citação: 
Journal of Clinical Anesthesia. New York: Elsevier B.V., v. 22, n. 5, p. 313-317, 2010.
Duração: 
313-317
Publicador: 
Elsevier B.V.
Palavras-chaves: 
  • Benzocaine
  • Dentistry
  • Drug encapsulation
  • Injection pain
  • Liposome
  • Local anesthetic
  • Topical anesthesia
Fonte: 
http://dx.doi.org/10.1016/j.jclinane.2010.03.001
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/42135
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