Please use this identifier to cite or link to this item:
- Influence of Tumour Condition on the Macrophage Activity in Candida albicans Infection
- Universidade Estadual Paulista (UNESP)
- Hosp Estadual Bauru
- Instituto Lauro de Souza Lima (ILSL)
- Fundação para o Desenvolvimento da UNESP (FUNDUNESP)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- To better understand the interactions between opportunistic fungi and their hosts, we investigated hydrogen peroxide (H(2)O(2)), nitric oxide and TNF-alpha production by peritoneal macrophages from Ehrlich tumour-bearing mice (TBM) during microbial infections. For this purpose, TBM at days 7, 14 and 21 of tumour progression were inoculated intraperitoneally with C. albicans and evaluated after 24 and 72 h. We observed that TBM showed significant increases in H(2)O(2), TNF-alpha levels and fungal clearance at day 7 after C. albicans infection. However, as the tumour advanced, there was a progressive decline in the release of H(2)O(2) and TNF-alpha that was paired with the dissemination of C. albicans. These results demonstrate that protective macrophage activities against Candida albicans are limited to the initial stages of tumour growth; continued solid tumour growth weakened the macrophage response and as a consequence, weakened the host's susceptibility to opportunistic infections.
- Scandinavian Journal of Immunology. Malden: Wiley-blackwell Publishing, Inc, v. 70, n. 1, p. 10-17, 2009.
- Wiley-Blackwell Publishing, Inc
- Acesso aberto
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.