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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/63646
Title: 
Supersensitivity of the isolated guinea-pig vas deferens induced by a toxic fraction of scorpion venom (Tityus serrulatus)
Author(s): 
Institution: 
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
ISSN: 
0742-8413
Abstract: 
1. Tityustoxin (TsTx), a toxic fraction of Tityus serrulatus venom, was studied on the isolated guinea-pig vas deferens. It increased significantly the maximal response of the preparation to both norepinephrine and acetylcholine and decreased the effective median dose of norepinephrine. 2. The effect of TsTx on norepinephrine median dose was unchanged when atropinized or pharmacologically 'denervated' preparations were used but was abolished when both procedures were associated. 3. Atropinization of pharmacologically denervated muscles almost never modify the TsTx-induced increase in the maximal response to norepinephrine. 4. On denervated or phentolamine-treated muscles TsTx-induced increase in the maximal response to acetylcholine was abolished. 5. It was concluded that toxin predominantly induces adrenergic postsynaptic supersensitivity. 6. Of minor significance, it also induces presynaptic cholinergic and adrenergic supersensitivity. 7. Comparison of these results with those of crude venom indicates that TsTx effects may result from the sum of the effects of subcomponents not demonstrated by the chemical procedures here utilized.
Issue Date: 
1-Jan-1984
Citation: 
Comparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinology, v. 78, n. 1, p. 171-173, 1984.
Time Duration: 
171-173
Keywords: 
  • acetylcholine
  • atropine
  • metirosine
  • noradrenalin
  • phentolamine
  • postsynaptic receptor
  • reserpine
  • scorpion venom
  • tityus toxin
  • animal cell
  • arthropod
  • autonomic nervous system
  • guinea pig
  • male genital system
  • nonhuman
  • supersensitivity
  • vas deferens
  • Acetylcholine
  • alpha-Methyltyrosine
  • Animal
  • Atropine
  • Guinea Pigs
  • In Vitro
  • Male
  • Methyltyrosines
  • Muscle, Smooth
  • Neurotoxins
  • Norepinephrine
  • Phentolamine
  • Receptors, Adrenergic
  • Receptors, Cholinergic
  • Scorpion Venoms
  • Vas Deferens
Source: 
http://dx.doi.org/10.1016/0742-8413(84)90065-3
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/63646
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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