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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/64345
Título: 
Considerações sobre o câncer localmente avançado de mama (CLAM) acrescidas de identificação dos receptores de estrogênios usando anticorpos monoclonais.
Título alternativo: 
Locally advanced cancer of the breast (LACB) and identification of estrogen receptors with monoclonal antibodies
Autor(es): 
Instituição: 
Universidade Estadual Paulista (UNESP)
ISSN: 
0104-4230
Resumo: 
The effects of therapy in locally advanced breast cancer submitted to combined conventional telecobalt therapy plus chemotherapy with cyclophosphamide and 5-fluorouracil were studied in 49 patients. Associated to radical mastectomy in operable cases. Local tumor control was achieved in 86.7%. There were no local recurrences in those submitted to surgery but they reached 21.7% in inoperable patients who received only radiation therapy and chemotherapy. The median follow-up time for dead patients was 29.5 months and for living patients 79.3 months. The index of complete responses was 24.5% and the median disease free interval was 22.9 months. The overall survival rate, between three and five years, was 32.7%. Estrogen receptors were identified by using immunohistochemical assay ER-ICA and monoclonal antibody H222-SP gamma, Abbott. There were no differences in the complete response index, disease free interval and survival rates, among ER-positive and ER-negative patients, explained by the far advanced stage of the disease. ER-positivity was significantly correlated with histological features of the tumors: cell differentiation, presence of elastosis, absence of lymphocytic infiltration and absence of tumor necrosis.
Data de publicação: 
1-Jan-1993
Citação: 
Revista da Associacao Medica Brasileira (1992), v. 39, n. 1, p. 17-32, 1993.
Duração: 
17-32
Palavras-chaves: 
  • estrogen receptor
  • monoclonal antibody
  • adult
  • aged
  • breast tumor
  • cancer staging
  • chemistry
  • comparative study
  • female
  • human
  • mortality
  • multimodality cancer therapy
  • pathology
  • prognosis
  • retrospective study
  • review
  • tumor recurrence
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Monoclonal
  • Breast Neoplasms
  • Combined Modality Therapy
  • Comparative Study
  • English Abstract
  • Female
  • Human
  • Middle Age
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Prognosis
  • Receptors, Estrogen
  • Retrospective Studies
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/64345
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