Please use this identifier to cite or link to this item:
- Increased oxygen radical and high-dietary-carbohydrate pancreatic damage.
- Universidade Estadual Paulista (UNESP)
- These data suggest that an improved understanding of the relationship between high dietary carbohydrate and the rate of lipid peroxidation may give some insight into possible treatment modalities for pancreatic damages and may shed light on molecular mechanisms underlying certain pathological processes. High dietary carbohydrate lesions are age related and induced alterations on ceruloplasmin, phospholipids, total proteins, copper and zinc serum levels. Significantly increased serum and pancreatic amylase, and lipoperoxide determinations were observed in 20 month old rats. Cu-Zn superoxide dismutase was decreased in these animals. Daily injection of Cu-Zn superoxide dismutase conjugated with polyethylene glycol (SOD-PEG) prevented the serum and pancreatic changes, indicating that superoxide radical is an important intermediate to high dietary carbohydrate lesion.
- Boletin de estudios medicos y biologicos, v. 42, n. 1-4, p. 21-25, 1994.
- macrogol derivative
- reactive oxygen metabolite
- superoxide dismutase
- carbohydrate diet
- pancreas disease
- rat strain
- Dietary Carbohydrates
- Pancreatic Diseases
- Polyethylene Glycols
- Rats, Wistar
- Reactive Oxygen Species
- Superoxide Dismutase
- Support, Non-U.S. Gov't
- Acesso restrito
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.