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- Effect of nicotinic stimulation of the amygdaloid complex on water and sodium chloride intake
- Universidade Estadual Paulista (UNESP)
- We studied the nicotine stimulation of the amygdaloid complex (AMG) on sodium and water intake in satiated and water-deprived rats. Nicotine produced no change in sodium or water intake in satiated animals when injected directly into the AMG. In water-deprived animals, nicotine injected into the AMG (basolateral nuclei) only blocked sodium chloride intake. We have previously demontrated that carbachol inhibits water and sodium intake in both satiated and water-deprived animals injected into the AMG. Injection of hexamethonium into the AMG totally blocked water intake in satiated and water-deprived animals. Hexamethonium injected into the AMG prior to nicotine produced no change in sodium intake. Thus, the present data suggest that sodium and water intake are mediated by a specific population of cholinoceptive neurons in the amygdaloid complex.
- Revista de Ciencias Biomedicas, v. 15, p. 41-48.
- amygdaloid complex
- sodium appetite
- water intake
- amygdaloid nucleus
- animal experiment
- cholinergic system
- controlled study
- drug effect
- fluid intake
- intracerebroventricular drug administration
- sodium intake
- Acesso restrito
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