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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/64560
Título: 
INFLUENCIA DO ACRESCIMO DE MANITOL A SOLUCAO NUTRIENTE NO DESEMPENHO MECANICO E NO GRAU DE EDEMA MIOCARDICO DE CORACOES ISOLADOS DE RATOS
Título alternativo: 
Influence of mannitol added to the perfusion solution on mechanical properties and myocardial edema of isolated rat hearts
Autor(es): 
Instituição: 
Universidade Estadual Paulista (UNESP)
ISSN: 
0066-782X
Resumo: 
Purpose - To analyse the influence of mannitol added to Krebs-Henseleit (KH) solution on the myocardium edema and myocardial function. Methods - Isolated rat heart under isovolumetric contractions studied according to Langendorff's technique were perfused with KH solution at constant flow during 90 min. The coronary perfusion pressure, diastolic and systolic pressures were recorded at every 15 min. At the end of the experiment, myocardium water content was measured in hearts perfused with KH solution (group I, n = 9) and in hearts perfused with KH solution plus 8 mM mannitol (group II, n = 8). These results were compared to non-perfused control heart (n = 9). Results - Myocardial water content was statistically higher in group I (80.8 ± 1.3%) compared to group II (78.1 ± 0.7%) and control group (75.5 ± 0.5%). Systolic arterial pressure was statistically higher in group I (86.2 ± 11.5 mmHg) compared to group II (72.7 ± 21.1 mmHg). There was no difference in the diastolic pressure between the two groups. Coronary perfusion pressure (Pp) increased progressively during the experiment in both groups. However, Pp was lower in group II than in group I. Conclusion - Mannitol added to KH solution significantly attenuates the myocardium edema in the isolated perfused rat heart.
Data de publicação: 
1-Jan-1995
Citação: 
Arquivos Brasileiros de Cardiologia, v. 64, n. 3, p. 225-229, 1995.
Duração: 
225-229
Palavras-chaves: 
  • mannitol
  • myocardial-edema
  • cardioplegic agent
  • glucose
  • krebs henseleit solution
  • Krebs-Henseleit solution
  • osmotic diuretic agent
  • trometamol
  • animal tissue
  • controlled study
  • coronary reperfusion
  • edema
  • heart function
  • myocardial disease
  • nonhuman
  • rat
  • animal
  • blood pressure
  • body water
  • comparative study
  • drug effect
  • heart contraction
  • heart edema
  • in vitro study
  • male
  • multivariate analysis
  • pathophysiology
  • rat strain
  • Animal
  • Blood Pressure
  • Body Water
  • Cardioplegic Solutions
  • Comparative Study
  • Diuretics, Osmotic
  • Edema, Cardiac
  • English Abstract
  • Glucose
  • In Vitro
  • Male
  • Mannitol
  • Multivariate Analysis
  • Myocardial Contraction
  • Rats
  • Rats, Wistar
  • Tromethamine
Fonte: 
http://www.arquivosonline.com.br/pesquisartigos/Pdfs/1995/V64N3/64030009.pdf
Endereço permanente: 
Direitos de acesso: 
Acesso aberto
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/64560
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