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- Genetic susceptibility to bleomycin: A twin study
- Universidade Estadual Paulista (UNESP)
- The frequency of chromatid breaks was analysed in peripheral lymphocytes obtained from sixteen healthy monozygotic (MZ) and sixteen healthy dizygotic (DZ) pairs of twins. In addition, increases in the frequency of chromatid breaks, following in vitro treatment of whole blood with 0.03 unit/ml bleomycin (BLM), were analysed in the same twins. There was a highly significant intrapair difference in the variance of the frequency of chromatid breaks among MZ and DZ twins, before and after BLM treatment. The coefficient of heritability was 85,5% and it was concluded that genetic factors contributed significantly to the individual variation observed in BLM induced chromatid break rates.
- Revista de Ciencias Biomedicas, v. 16, p. 47-53.
- variation (genetics)
- chromosome breakage
- dizygotic twins
- genetic susceptibility
- human experiment
- in vitro study
- monozygotic twins
- normal human
- Acesso restrito
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