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Peripheral giant cell granuloma. An immunohistochemical and ultrastructural study.
Universidade Estadual Paulista (UNESP)
OBJECTIVE: To study the nature of multinucleated and mononuclear cells from peripheral giant cell granuloma (PGCG). MATERIALS AND METHODS: Formalin-fixed, paraffin-embedded sections of 40 cases of PGCG were immunohistochemically stained for vimentin, alpha I-antichymotrypsin, CD68, S-100 protein, lysozyme, leucocyte common antigen (LCA), factor VIII-related antigen and muscle cell actin. Six cases of PGCG were also studied by transmission electron microscopy. RESULTS: Vimentin, alpha I-antichymotrypsin and CD68 were expressed in both the mononuclear and multinucleated giant cells. Dendritic mononuclear cells, positive for S-100 protein, were noted in 67.5% of the lesions, whereas lysozyme and leucocyte common antigen were detected in occasional mononuclear cells. Ultrastructural examination showed mononuclear cells with signs of phagocytosis and sometimes interdigitations with similar cells. Others presented non-specific characteristics and the third type exhibited cytoplasmic processes and occasional Birbeck granules. Some multinucleated giant cells showed oval nuclei, abundant mitochondria and granular endoplasmic reticulum whereas others presented with irregular nuclei and a great number of cytoplasmic vacuoles. CONCLUSIONS: Immunohistochemical and ultrastructural results suggest that PGCGs of the jaws are composed mainly of cells of the mononuclear phagocyte system and that Langerhans cells are present in two thirds of the lesions.
Issue Date: 
Oral diseases, v. 1, n. 1, p. 20-25, 1995.
Time Duration: 
  • actin
  • alpha 1 antichymotrypsin
  • CD45 antigen
  • CD68 antigen, human
  • differentiation antigen
  • leukocyte antigen
  • lysozyme
  • monoclonal antibody
  • protein S 100
  • vimentin
  • von Willebrand factor
  • chemistry
  • electron microscopy
  • enzyme immunoassay
  • giant cell
  • giant cell granuloma
  • gingiva disease
  • human
  • Langerhans cell
  • pathology
  • phagocyte
  • retrospective study
  • ultrastructure
  • Actins
  • alpha 1-Antichymotrypsin
  • Antibodies, Monoclonal
  • Antigens, CD
  • Antigens, CD45
  • Antigens, Differentiation, Myelomonocytic
  • Giant Cells
  • Gingival Diseases
  • Granuloma, Giant Cell
  • Human
  • Immunoenzyme Techniques
  • Langerhans Cells
  • Microscopy, Electron
  • Muramidase
  • Phagocytes
  • Retrospective Studies
  • S100 Proteins
  • Vimentin
  • von Willebrand Factor
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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