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Estudo sobre a resistencia aos antimicrobianos em bacterias isoladas de pacientes hospitalizados (Botucatu, 1988-1992)
Other Titles: 
A survey of resistance to antimicrobial drugs in isolated bacterias from hospitalized patients (Botucatu, 1988-1992)
Universidade Estadual Paulista (UNESP)
Since 1988 to 1992, a study about susceptibility to antimicrobial drugs of bacterias isolated from hospitalized patients was performed. The compared susceptibility to important drugs (ampicillin, cephalotin, cefoxitin, ceftaxizime, ceftriaxone, aztreonam, gentamicin, amikacin, pefloxacin, ciprofloxacin, imipenem, oxacillin and vancomycin) was investigated in 1200 strains (300 of each specie) of the prevalent bacterias: E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and S. aureus. Minimal inhibitory concentration (MIC) was determined by agar dilution method, using from 0.05 to 256 mcg of each drug per ml of culture medium (Mueller-Hinton). Ranges of MIC, MIC(50%), MIC(90%) and the proportion of resistant strains were determined and permitted to know the 4 drugs that were found to be more active against bacterias; the CIM(90%) values are: E. coli - aztreonam (0.1 mcg/ml), pefloxacin (0.1), ceftazidime (0.25) and ceftriaxone (0.05); K. pneumoniae-aztreonam (0.25) ceftriaxone (0.25), ceftazidime (0.5) and pefloxacin (2.0); P. aeruginosa-imipenem (4.0), aztreonam (16), ceftazidime (16) and ciprofloxacin (16); S. aureus-vancomycin (1.01, ciprofloxacin (8, 0), amikacin (128) and cephalothin (128 mg/ml). The better 'in vitro' antibacterial activity observed was related to: aztreonam (77-100% of the sensitive strains), ceftazidime (50-99,7%), pefloxacin (73-99,7%), ciprofloxacin (80%), imipenem (93%) and vancomycin (100%).
Issue Date: 
Folha Medica, v. 113, n. 1, p. 91-97, 1996.
Time Duration: 
  • antimicrobial drugs
  • bacterial sensitivity
  • hospital infection
  • amikacin
  • ampicillin
  • antibiotic agent
  • aztreonam
  • cefalotin
  • cefoxitin
  • ceftazidime
  • ceftriaxone
  • ciprofloxacin
  • gentamicin
  • imipenem
  • oxacillin
  • pefloxacin
  • vancomycin
  • antibiotic resistance
  • antibiotic sensitivity
  • controlled study
  • escherichia coli
  • hospital
  • human
  • klebsiella pneumoniae
  • minimum inhibitory concentration
  • nonhuman
  • pseudomonas aeruginosa
  • staphylococcus aureus
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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