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The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution
  • Georgetown Univ
  • CSIRO Livestock Ind
  • Baylor Coll Med
  • Washington Univ
  • Texas A&M Univ
  • Univ Adelaide
  • University of Washington
  • Howard Hughes Med Inst
  • Natl Human Genome Res Inst
  • Univ Pompeu Fabra
  • USDA
  • Univ Oriente
  • Univ Saskatchewan
  • INRA UR1196
  • Univ Ljubljana
  • Res Inst Biol Farm Anim FBN
  • Univ Wisconsin Madison
  • University of Guelph
  • EMBL Heidelberg
  • ITACyL
  • Univ Wisconsin
  • Monsanto Co
  • Natl Bur Anim Genetic Res
  • Agr & Agri-Food Canada
  • Univ Cattolica Sacro Cuore
  • Univ California Davis
  • Universidade Estadual Paulista (UNESP)
  • Norwegian Sch Vet Sci
  • INTA
  • Natl Univ Singapore
  • Univ Antioquia
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  • USDA Agr Res Serv
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  • Swiss Inst Bioinformatics
  • Imperial Coll
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  • Univ London
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  • AgRes
  • Univ Adelaide N Terrace
  • Catalan Inst Res & Adv Studies
  • Iowa State Univ
  • Bovine Functional Genomics Lab
  • George Mason Univ
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  • Daily Sci & Tech Section
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  • Nestle Res Ctr
  • Bioinformatics Mathematics Stat
  • Chungnam Natl Univ
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  • Univ Edinburgh
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  • Inst Anim Hlth
  • Univ Helsinki
  • Wellcome Trust Sanger Inst
  • Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
  • Texas AgriLife Res
  • Mississippi State Univ
  • Polo Univ
  • NIH
  • British Columbia Canc Agcy
  • Natl Inst Agrobiol Sci
  • Univ California Santa Cruz
  • Columbia University
  • INRA
  • Pfizer Anim Hlth
  • Norwegian Univ Life Sci
  • Uppsala Univ
  • Shirakawa Inst Anim Genetics
  • Universidade de São Paulo (USP)
  • MTT Agrifood Res Finland
  • Macquarie Univ
  • National Human Genome Research Institute
  • U.S. Department of Agriculture's Agricultural Research Service
  • Cooperative State Research, Education, and Extension Service National Research Initiative
  • the state of Texas
  • Genome British Columbia
  • Alberta Science and Research Authority
  • Commonwealth Scientific and Industrial Research Organization of Australia (CSIRO)
  • Agritech Investments Ltd
  • Dairy Insight, Inc
  • AgResearch Ltd.
  • Research Council of Norway
  • Kleberg Foundation
  • National, Texas, and South Dakota Beef Check-off Funds
Sponsorship Process Number: 
  • NHGRI: U54 HG003273
  • U.S. Department of Agriculture's Agricultural Research Service: 59-0790-3-196
  • Cooperative State Research, Education, and Extension Service National Research Initiative: 2004-35216-14163
To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
Issue Date: 
Science. Washington: Amer Assoc Advancement Science, v. 324, n. 5926, p. 522-528, 2009.
Time Duration: 
Amer Assoc Advancement Science
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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