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Functional evidence that the central renin-angiotensin system plays a role in the pressor response induced by central injection of carbachol
Universidade Estadual Paulista (UNESP)
We investigated the effects of losartan, an AT 1-receptor blocker, and ramipril, a converting enzyme inhibitor, on the pressor response induced by angiotensin II (ANG II) and carbachol (a cholinergic receptor agonist). Male Holtzman rats (250-300 g) with a stainless steel cannula implanted into the lateral ventricle (LV) were used. The injection of losartan (50 nmol/l μl) into the LV blocked the pressor response induced by ANG II (12 ng/l μl) and carbachol (2 nmol/l μl). After injection of ANG II and carbachol into the LV, mean arterial pressure (MAP) increased to 31 ± 1 and 28 ± 2 mmHg, respectively. Previous injection of losartan abolished the increase in MAP induced by ANG II and carbachol into the LV (2 ± 1 and 5 ± 2 mmHg, respectively). The injection of ramipril (12 ng/l μl) prior to carbachol blocked the pressor effect of carbachol to 7 ± 3 mmHg. These results suggest an interaction between central cholinergic pathways and the angiotensinergic system in the regulation of arterial blood pressure.
Issue Date: 
Brazilian Journal of Medical and Biological Research, v. 30, n. 4, p. 493-496, 1997.
Time Duration: 
  • carbachol
  • central angiotensin
  • pressor response
  • angiotensin
  • losartan
  • losartan potassium
  • ramipril
  • animal experiment
  • cholinergic system
  • conference paper
  • controlled study
  • intracerebroventricular drug administration
  • male
  • nonhuman
  • rat
  • renin angiotensin aldosterone system
  • Angiotensin-Converting Enzyme Inhibitors
  • Animals
  • Blood Pressure
  • Carbachol
  • Cerebral Ventricles
  • Cholinergic Agonists
  • Losartan
  • Male
  • Pressoreceptors
  • Ramipril
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Angiotensin
  • Renin-Angiotensin System
  • Animalia
Access Rights: 
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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