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Plasma levels of transthyretin and retinol-binding protein in child-a cirrhotic patients in relation to protein-calorie status and plasma amino acids, zinc, vitamin a and plasma thyroid hormones
Universidade Estadual Paulista (UNESP)
Transthyretin and retinal-binding protein are sensitive markers of acute protein-calorie malnutrition both for early diagnosis and dietary evaluation. A preliminary study showed that retinal-binding protein is the most sensitive marker of protein-calorie malnutrition in cirrhotic patients, even those with the mild form of the disease (Child A). However, in addition to being affected by protein-calorie malnutrition, the levels of these short half-life-liver-produced proteins are also influenced by other factors of a nutritional (zinc, tryptophan, vitamin A, etc) and non-nutritional (sex, aging, hormones, renal and liver functions and inflammatory activity) nature. These interactions were investigated in 11 adult male patients (49.9 ± 9.2 years of age) with alcoholic cirrhosis (Child-Pugh grade A) and with normal renal function. Both transthyretin and retinol binding protein were reduced below normal levels in 55% of the patients, in close agreement with their plasma levels of retinal. In 67% of the patients (4/6), the reduced levels of transthyretin and retinal-binding protein were caused by altered liver function and in 50% (3/6) they were caused by protein-calorie malnutrition. Thus, the present data, taken as a whole, indicate that reduced transthyretin and retinal-binding protein levels in mild cirrhosis of the liver are mainly due to liver failure and/or vitamin A status rather than representing an isolated protein-calorie malnutrition indicator.
Issue Date: 
Arquivos de Gastroenterologia, v. 34, n. 3, p. 139-147, 1997.
Time Duration: 
  • Liver cirrhosis
  • Prealbumin
  • Protein binding
  • Protein-calorie malnutrition
  • Vitamin A
  • amino acid
  • prealbumin
  • retinol
  • retinol binding protein
  • thyroid hormone
  • zinc
  • adult
  • alcohol liver cirrhosis
  • blood
  • human
  • liver failure
  • male
  • metabolism
  • middle aged
  • protein calorie malnutrition
  • Adult
  • Amino Acids
  • Humans
  • Liver Cirrhosis, Alcoholic
  • Liver Failure
  • Male
  • Middle Aged
  • Protein-Energy Malnutrition
  • Retinol-Binding Proteins
  • Thyroid Hormones
  • Zinc
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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