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Paracoccidioidomycosis: Survey and clinical aspects from the Department of Dermatology of the School of Medicine of Botucatu (Sao Paulo - Brazil)
Universidade Estadual Paulista (UNESP)
Background - Paracoccidioidomycosis is the most frequent among the systemic mycoses in Brazil. Objective: To study the cases of paracoccidioidomycosis diagnosed from 1976 to 1996 at the Department of Dermatology of the School of Medicine of Botucatu. Methods - Descriptive study obtained from specific protocols comprising anamnesis, clinical- dermatological-laboratorial examination, treatment and follow-up of the patients. Results - Paracoccidioidomycosis was diagnosed in 1.04% of the dermatologic outpatients assisted from 1976 to 1996. In 315 cases, 89.8% were male, 61.9% were over forty and 53.7% were rural workers. The complaints were related more to oropharyngolaryngeal (53.6%) or cutaneous (23.8%) lesions or adenopathy (10.2%). Seventy patients had already been treated in other health services. The chronic multifocal clinical from was the most common: 80.6% of the cases, followed by the acute-subacute (juvenile type) 15.5%. The disease was pulmonary in 80.0%, oropharyngolaryngeal in 69.2% and cutaneous in 45.7%. Th treatment: Amphotericin B in 146 patients, Ketoconazole - 88, Itraconazole - 56, Sulfonamide derivatives - 146 and Terbinafine in 3. The lethality index resulting from the disease or its treatment was 2.0%. Conclusions - The high number of cases, showing the regional relevance of the disease and the high percentage of tegumentary complaints and the high number of relapsing are remarkable.
Issue Date: 
Anais Brasileiros de Dermatologia, v. 73, n. 5, p. 411-417, 1998.
Time Duration: 
  • Epidemiology
  • Mycoses
  • Paracoccidioidomycosis
  • amphotericin b
  • itraconazole
  • ketoconazole
  • sulfonamide
  • terbinafine
  • adult
  • antifungal activity
  • Brazil
  • clinical protocol
  • female
  • human
  • major clinical study
  • male
  • relapse
  • south american blastomycosis
  • treatment outcome
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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