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Insulin secretion in monosodium glutamate (MSG) obese rats submitted to aerobic exercise training
Universidade Estadual Paulista (UNESP)
The present study was designed to evaluate the effects of aerobic exercise training on glucose tolerance and insulin secretion of obese male Wistar rats (monosodium glutamate [MSG] administration, 4mg/g-body weight, each other day, from birth to the 14th day). Fourteen weeks after the drug administration, the rats were separated into two groups: MSG-S (sedentary) and MSG-T (T = swimming, 1 h/day, 5 days/week, with an overload of 5% body weight for 10 weeks). Rats of the same age and strain injected with saline were used as control (C) and subdivided into two groups: C-S and C-T. Insulin and glucose responses during an oral glucose tolerance test (GTT) were evaluated by the estimation of the total areas under serum insulin (AI) and glucose (AG) curves. Glucose-induced insulin secretion by isolated pancreatic islets was also evaluated. MSG-S rats showed higher AI than C-rats while MSG-T rats presented lower AI than MSG-S rats. No differences in AG were observed among the 4 groups. Pancreatic islets from MSG-rats showed higher insulin secretion in response to low (2.8) and moderate (8.3 mM) concentrations of glucose than those from their control counterparts and no differences were observed between MSG-S and MSG-T rats. These results provide evidences that the hyperinsulinemia at low or moderate glucose concentrations observed in MSG-obese rats is, at least in part, a consequence of direct hypersecretion of the B cells and that chronic aerobic exercise is able to partially counteract the hyperinsulinemic state of these animals without disrupting glucose homeostasis.
Issue Date: 
Physiological Chemistry and Physics and Medical NMR, v. 35, n. 1, p. 43-53, 2003.
Time Duration: 
  • glucose
  • glutamate sodium
  • insulin
  • sodium chloride
  • aerobic metabolism
  • age distribution
  • animal cell
  • animal experiment
  • animal tissue
  • B lymphocyte
  • body weight
  • controlled study
  • exercise
  • female
  • glucose homeostasis
  • glucose tolerance
  • insulin blood level
  • insulin release
  • insulin response
  • male
  • nonhuman
  • obesity
  • oral glucose tolerance test
  • pancreas islet
  • physical activity
  • rat
  • strain difference
  • swimming
  • Animals
  • Blood Glucose
  • Body Weight
  • Fats
  • Female
  • Glucose
  • Glucose Tolerance Test
  • Insulin
  • Lactic Acid
  • Male
  • Obesity
  • Pancreas
  • Physical Conditioning, Animal
  • Rats
  • Rats, Wistar
  • Sodium Glutamate
  • Animalia
  • Rattus norvegicus
Access Rights: 
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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