You are in the accessibility menu

Please use this identifier to cite or link to this item:
Toxicity of hypercaloric diet and monosodium glutamate: oxidative stress and metabolic shifting in hepatic tissue.
Universidade Estadual Paulista (UNESP)
The present study examines the effects of a hypercaloric diet on hepatic glucose metabolism of young rats, with and without monosodium glutamate (MSG) administration, and the association of these treatments with evaluating markers of oxidative stress. Male weaned Wistar rats (21 days old) from mothers fed with a hypercaloric diet or a normal diet, were divided into four groups (n=6): control (C) fed with control diet; (MSG) treated with MSG (4 mg/g) and control diet; (HD) fed with hypercaloric diet and (MSG-HD) treated with MSG and HD. Rats were sacrificed after the oral glucose tolerance test (OGTT), at 45 days of treatments. Serum was used for insulin determination. Glycogen, hexokinase(HK), glucose-6-phosphatase(G6PH), lipid hydroperoxide, superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) were determined in liver. HD rats showed hypoglycemia, hyperinsulinemia, and high hepatic glycogen, HK and decreased G6PH. MSG and MSG-HD had hyperinsulinemia, hyperglycemia, decreased HK and increased G6PH in hepatic tissue. These animals had impaired OGTT. HD, MSG and MSG-HD groups had increased lipid hydroperoxide and decreased SOD in hepatic tissue. Hypercaloric diet and monosodium glutamate administration induced alterations in metabolic rate of glucose utilization and decreased antioxidant defenses. Therefore, the hepatic glucose metabolic shifting induced by HD intake and MSG administration were associated with oxidative stress in hepatic tissue.
Issue Date: 
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, v. 42, n. 2, p. 313-319, 2004.
Time Duration: 
  • flavoring agent
  • glucose
  • glutamate sodium
  • insulin
  • animal
  • blood
  • diet
  • drug effect
  • female
  • liver
  • male
  • metabolism
  • newborn
  • oxidative stress
  • rat
  • Wistar rat
  • Animals
  • Animals, Newborn
  • Diet
  • Female
  • Flavoring Agents
  • Glucose
  • Insulin
  • Liver
  • Male
  • Oxidative Stress
  • Rats
  • Rats, Wistar
  • Sodium Glutamate
Access Rights: 
Acesso restrito
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.