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Cyclosporin but not tacrolimus significantly increases salivary cytokine contents in rats
  • Universidade Estadual Paulista (UNESP)
  • Universidade de São Paulo (USP)
Background: Cyclosporin (CsA) and tacrolimus (FK-506) are immunosuppressive drugs that specifically inhibit T-cell activation via calcineurin inhibition. Gingival overgrowth is a common side effect following the administration of CsA. The severity of gingival overgrowth seen in patients taking FK-506 is less than that observed with CsA. Little is known about the involvement of saliva in drug-induced gingival overgrowth. The purpose of this study was to investigate the salivary contents of tumor growth factor β1 (TGF-β1), epidermal growth factor (EGF), and interleukin-6 (IL-6) as well as the hystometry of gingival tissue obtained from rats treated with either FK-506 or CsA. Methods: For 30 or 60 days rats received daily subcutaneous injection doses of either CsA or FK-506 (10 mg/kg). The concentrations of TGF-β1, EGF, and IL-6 in saliva were determined by enzyme-linked immunosorbent assay, and after histological processing, the oral epithelium and connective tissue were assessed at the region of the lower first molars. Results: The levels of TGF-β1, EGF, and IL-6 in saliva were not significantly altered by any of the treatments after 30 days. After 60 days of treatment with CsA, gingival overgrowth and significant increase in salivary TGF-β1, EGF, and IL-6 concentrations were observed; no statistically significant changes were induced by FK-506. Conclusion: Within the limits of this experimental study, it can be concluded that CsA, but not FK-506, induced gingival overgrowth associated with an increase of the salivary levels of the cytokines TGF-β1, EGF, and IL-6.
Issue Date: 
Journal of Periodontology, v. 76, n. 9, p. 1520-1525, 2005.
Time Duration: 
  • Animal studies
  • Cyclosporin A/adverse effects
  • Gingival hyperplasia/etiology
  • Growth factors, epidermal
  • Growth factors, tumor β1
  • Interleukin-6
  • Saliva/analysis
  • Tacrolimus/adverse effects
  • cyclosporin
  • cytokine
  • epidermal growth factor
  • interleukin 6
  • tacrolimus
  • transforming growth factor beta1
  • animal experiment
  • animal model
  • animal tissue
  • concentration response
  • connective tissue
  • controlled study
  • enzyme linked immunosorbent assay
  • fibroblast
  • gingiva overgrowth
  • histometry
  • male
  • molar tooth
  • mouth mucosa
  • nonhuman
  • rat
  • salivation
  • Animals
  • Cyclosporine
  • Cytokines
  • Epidermal Growth Factor
  • Gingival Overgrowth
  • Immunosuppressive Agents
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Saliva
  • Tacrolimus
  • Transforming Growth Factor beta
  • Transforming Growth Factor beta1
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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