Advances in prodrug design

Távora de Albuquerque Silva, Antonio; Chin, Chung Man; Castro, Lúcia Fioravanti; Carvalho Güido, Rafael Victorio; Ferreira, Elizabeth Igne

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/68433

Title:

Advances in prodrug design

Author(s):

Institution:

Universidade Estadual Paulista (UNESP)
Universidade de São Paulo (USP)

ISSN:

1389-5575

Abstract:

The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene-Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given. © 2005 Bentham Science Publishers Ltd.

Issue Date:

1-Oct-2005

Citation:

Mini-Reviews in Medicinal Chemistry, v. 5, n. 10, p. 893-914, 2005.

Time Duration:

893-914

Keywords:

Latent advanced systems
Macromolecules carriers
Prodrug design
Selective delivery systems
aminosalicylic acid
ampicillin
antiinflammatory agent
antileishmanial agent
antimalarial agent
antineoplastic agent
bisphosphonic acid derivative
cytochrome P450
diclofenac
doxorubicin
flucytosine
ibuprofen
irinotecan
isoniazid
ketoprofen
mevinolin
mitomycin
nitrofural
paclitaxel derivative
photosensitizing agent
prodrug
salazosulfapyridine
tacrolimus
testosterone derivative
tiaprofenic acid
tolmetin
trigonelline
tryptamine derivative
unindexed drug
antibody directed enzyme prodrug therapy
bactericidal activity
binding affinity
blood brain barrier
Chagas disease
diarrhea
drug absorption
drug activation
drug design
drug distribution
drug identification
drug receptor binding
drug screening
drug selectivity
drug stability
drug structure
drug synthesis
drug targeting
drug transformation
gastrointestinal toxicity
gene expression
human
hypercholesterolemia
in vivo study
macromolecule
malaria
minimum inhibitory concentration
nephrotoxicity
organoleptic property
osteoporosis
review
rheumatoid arthritis
structure activity relation
structure analysis
tuberculosis
ulcerative colitis
Animals
Antibodies
Drug Carriers
Drug Delivery Systems
Drug Design
Gene Therapy
Humans
Lectins
Macromolecular Substances
Osteoporosis
Prodrugs
Viruses

Source:

http://dx.doi.org/10.2174/138955705774329528

URI:

Access Rights:

Acesso restrito

Type:

outro

Source:

http://repositorio.unesp.br/handle/11449/68433

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