You are in the accessibility menu

Please use this identifier to cite or link to this item:
Kaposi's sarcoma-associated herpesvirus infection and Kaposi's sarcoma in Brazil
  • Universidade Estadual Paulista (UNESP)
  • Consultoria em Patologia
  • 0100-879X
  • 1678-4510
Kaposi's sarcoma (KS) became a critical health issue with the emergence of acquired immunodeficiency syndrome (AIDS) in the 1980s. Four clinical-epidemiological forms of KS have been described: classical KS, endemic KS,iatrogenic KS, and AIDS-associated KS. In 1994, Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus type 8 was identified by Chang and colleagues, and has been detected worldwide at frequencies ranging from 80 to 100%. The aim of the present study was to evaluate the frequency of KSHV infection in KS lesions from HIV-positive and HIV-negative patients in Brazil, as well as to review the current knowledge about KS transmission and detection. For these purposes, DNA from 51 cases of KS was assessed by PCR: 20 (39.2%) cases of classical KS, 29 (56.9%) of AIDS-associated KS and 2 (3.9%) of iatrogenic KS. Most patients were males (7.5:1, M/F), and mean age was 47.9 years (SD = ± 18.7 years). As expected, HIV-positive KS patients were younger than patients with classical KS. On the other hand, patients with AIDS-associated KS have early lesions (patch and plaque) compared to classical KS patients (predominantly nodular lesions). This is assumed to be the result of the early diagnose of KS in the HIV-positive setting. KSHV infection was detected by PCR in almost all cases (48/51; 94.1%), irrespectively of the clinical-epidemiological form of KS. These results show that KSHV is associated with all forms of KS in Brazilian patients, a fact that supports the role of this virus in KS pathogenesis. © 2006 Brazilian Journal of Medical and Biological Research.
Issue Date: 
Brazilian Journal of Medical and Biological Research, v. 39, n. 5, p. 573-580, 2006.
Time Duration: 
  • Brazil
  • Human herpesvirus type 8
  • Kaposi's sarcoma
  • Kaposi's sarcoma-associated herpesvirus
  • Polymerase chain reaction
  • Viral carcinogenesis
  • DNA
  • adolescent
  • adult
  • age distribution
  • cancer staging
  • controlled study
  • disease association
  • disease classification
  • DNA determination
  • early diagnosis
  • epidemic
  • female
  • frequency analysis
  • herpes
  • human
  • Human herpesvirus 8
  • Human immunodeficiency virus infection
  • human tissue
  • Kaposi sarcoma
  • major clinical study
  • male
  • pathophysiology
  • polymerase chain reaction
  • skin biopsy
  • virus genome
  • virus identification
  • virus transmission
  • AIDS-Related Opportunistic Infections
  • Amino Acid Sequence
  • DNA, Viral
  • Female
  • Genome, Viral
  • Herpesvirus 8, Human
  • Humans
  • Male
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Sarcoma, Kaposi
  • Herpes
  • Herpesviridae
  • Human immunodeficiency virus
Access Rights: 
Acesso aberto
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.