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The effects of up to 240 days of tacrolimus therapy on the gingival tissues of rats - A morphological evaluation
  • Universidade Estadual Paulista (UNESP)
  • Universidade Estadual do Oeste do Paraná (UNIOESTE)
  • 1354-523X
  • 1601-0825
Background: Tacrolimus, an immunosuppressive drug used in organ transplantation, has been reported not to induce gingival overgrowth. However, prevalence studies are limited, and the methods used for assessing gingival overgrowth varies among studies. Objective: The purpose of this study was to evaluate the effects of up to 240 days of tacrolimus therapy on gingival tissues of rats. Materials and methods: Rats were treated for 60, 120, 180 and 240 days with daily subcutaneous injections of 1 mg/kg body weight of tacrolimus. After histological processing, the oral and connective tissue, volume densities of fibroblasts (Vf), collagen fibers (Vcf) and other structures (Vo) were assessed in the region of the lower first molar. Results: After 60 and 120 days of treatment with tacrolimus, gingival overgrowth was not observed. The gingival epithelium, connective tissue, as well as the values for Vf, Vcf, and Vo were similar to those of the control rats (P > 0.05). After 180 and 240 days of the treatment, gingival overgrowth was associated with a significant increase in the gingival epithelium and connective tissue as well as an increase in the V f and Vcf (P < 0.05). Conclusions: Within the limits of the experimental study, it may be concluded that the deleterious side effects of tacrolimus on the gingival tissues of rats may be time-related. © 2007 Blackwell Munksgaard All rights reserved.
Issue Date: 
Oral Diseases, v. 14, n. 1, p. 67-72, 2008.
Time Duration: 
  • Animal study
  • Gingival overgrowth
  • Immunosuppression drugs
  • Tacrolimus
  • collagen
  • tacrolimus
  • animal experiment
  • animal model
  • animal tissue
  • connective tissue
  • controlled study
  • drug effect
  • fibroblast
  • gingiva
  • gingiva overgrowth
  • histology
  • male
  • molar tooth
  • mouth
  • nonhuman
  • priority journal
  • rat
  • Sprague Dawley rat
  • statistical significance
  • Animals
  • Cell Count
  • Collagen
  • Connective Tissue
  • Epithelium
  • Fibroblasts
  • Gingiva
  • Gingival Hyperplasia
  • Gingival Overgrowth
  • Immunosuppressive Agents
  • Injections, Subcutaneous
  • Male
  • Mouth Mucosa
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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