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Methotrexate improves the health-related quality of life of children with juvenile idiopathic arthritis
  • Servizio di Epidemiologia e Biostatistica
  • Università degli Studi
  • Rheumatology Department
  • Istituto Gaetano Pini
  • Wilhelmina Kinderziekenhuis
  • Royal Alexandra Hospital
  • Hospital Universitario La Fe
  • Clinica Pediatrica
  • Pediatric Rheumatology
  • Ospedale Pediatrico Bambin Gesù
  • Universita' degli Studi di Trieste
  • Hackensack Medical Center
  • University Hospital Gasthuisberg
  • Centro Medico Nacional La Raza
  • Hospital General de México
  • Instituto de Puericultura e Pediatria Martagao Gesteira
  • Universidade Estadual Paulista (UNESP)
Objectives: To examine the change in health-related quality of life (HRQOL) and its determinants in children with juvenile idiopathic arthritis (JIA) treated with methotrexate (MTX). Methods: Patients were extracted from the PRINTO clinical trial which aimed to evaluate the efficacy and safety profile of MTX administered in standard, intermediate or higher doses (10, 15 and 30 mg/m2/week respectively). Children with polyarticular-course JIA, who were less than 18 years and had a complete HRQOL assessment were included. Results: A total of 521 children were included. At baseline, patients with JIA showed poorer HRQOL (p<0.01) than healthy children. In 207/412 (50%) and 63 (15%) children, HRQOL values were 2 standard deviations below the mean of healthy controls in the physical and psychosocial summary scale, respectively. After 6 months of treatment with standard dose MTX, there was a statistically significant improvement in all HRQOL health concepts, particularly the physical ones. Similar improvements were observed in those who did not respond to a standard dose of MTX and were subsequently randomised to a higher dose. The presence of marked disability at baseline was associated with a fivefold increased risk of retaining poor physical health after 6 months of active treatment with standard dose MTX. Other less important determinants of retaining poor physical well-being were the baseline level of systemic inflammation, pain intensity and an antinuclear-antibody-negative status. Conclusions: MTX treatment produces a significant improvement across a wide range of HRQOL components, particularly in the physical domains, in patients with JIA.
Issue Date: 
Annals of the Rheumatic Diseases, v. 67, n. 3, p. 309-314, 2008.
Time Duration: 
  • methotrexate
  • adolescent
  • child
  • child care
  • clinical feature
  • clinical trial
  • controlled clinical trial
  • controlled study
  • disability
  • disease severity
  • dose response
  • drug dose comparison
  • drug response
  • erythrocyte sedimentation rate
  • functional status
  • human
  • juvenile rheumatoid arthritis
  • major clinical study
  • priority journal
  • quality of life
  • randomized controlled trial
  • scoring system
  • treatment outcome
  • wellbeing
  • Adolescent
  • Antirheumatic Agents
  • Arthritis, Juvenile Rheumatoid
  • Child
  • Child, Preschool
  • Disability Evaluation
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Immunosuppressive Agents
  • Male
  • Methotrexate
  • Quality of Life
  • Recovery of Function
  • Severity of Illness Index
  • Treatment Outcome
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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