You are in the accessibility menu

Please use this identifier to cite or link to this item:
Efeito sinérgico entre a dexmedetomidina e a ropivacaína 0,75% na anestesia peridural
Other Titles: 
Synergistic effect between dexmedetomidine and 0.75% ropivacaine in epidural anesthesia
Universidade Estadual Paulista (UNESP)
BACKGROUND. This study aimed to evaluate clinical characteristics of epidural anesthesia performed with 0.75% ropivacaine associated with dexmedetomidine. METHODS. Forty patients scheduled for hernia repair or varicose vein surgeries under epidural anesthesia participated in this study. They were assigned to: Control Group (n = 20), 0.75% ropivacaine, 20 ml (150 mg); and Dexmedetomidine Group (n = 20), 0.75% ropivacaine, 20 ml (150 mg), plus dexmedetomidine, 1 μ -1. The following variables were studied: total analgesic block onset time, upper level of analgesia, analgesic and motor block duration time, intensity of motor block, state of consciousness, hemodynamics, postoperative analgesia and incidence of side-effects. RESULTS. Epidural dexmedetomidine did not affect onset time or upper level of anesthesia (p > 0.05) however it prolonged sensory and motor block duration time (p < 0.05) and postoperative analgesia (p < 0.05), and also resulted in a more intense motor block, 1 (p < 0.05). Values of bispectral index were lower in Dexmedetomidine Group (p < 0.05). There was no difference in incidence of hypotension and bradycardia (p > 0.05). Occurrence of side-effects (shivering, vomiting and SpO 2 < 90%) was low and similar between groups (p > 0.05). CONCLUSION. There is clear synergism between epidural dexmedetomidine and ropivacaine, further this drug association does not bring about additional morbidity.
Issue Date: 
Revista da Associacao Medica Brasileira, v. 54, n. 2, p. 110-115, 2008.
Time Duration: 
  • Analgesics
  • Anesthetic techniques
  • Anesthetics
  • Dexmedetomidine
  • Epidural block
  • Ropivacaine
  • alpha adrenergic receptor stimulating agent
  • amide
  • dexmedetomidine
  • local anesthetic agent
  • ropivacaine
  • adolescent
  • adult
  • chi square distribution
  • clinical trial
  • controlled clinical trial
  • controlled study
  • double blind procedure
  • drug potentiation
  • epidural anesthesia
  • female
  • human
  • inguinal hernia
  • leg
  • male
  • middle aged
  • nerve block
  • nonparametric test
  • randomized controlled trial
  • time
  • Adolescent
  • Adrenergic alpha-Agonists
  • Adult
  • Amides
  • Anesthesia, Epidural
  • Anesthetics, Local
  • Chi-Square Distribution
  • Double-Blind Method
  • Drug Synergism
  • Female
  • Hernia, Inguinal
  • Humans
  • Lower Extremity
  • Male
  • Middle Aged
  • Nerve Block
  • Statistics, Nonparametric
  • Time Factors
  • Young Adult
Access Rights: 
Acesso aberto
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.