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Obsessive-compulsive disorder: Influence of age at onset on comorbidity patterns
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
  • Porto Alegre Institute University Center
  • Obsessive-Compulsive Disorder Brazilian Consortium (C-TOC)
Purpose: This study investigates the influence of age at onset of OCS on psychiatric comorbidities, and tries to establish a cut-off point for age at onset. Methods: Three hundred and thirty OCD patients were consecutively recruited and interviewed using the following structured interviews: Yale-Brown Obsessive Compulsive Scale; Yale Global Tic Severity Scale and the Structured Clinical Interview for DSM-IV. Data were analyzed with regression and cluster analysis. Results: Lower age at onset was associated with a higher probability of having comorbidity with tic, anxiety, somatoform, eating and impulse-control disorders. Longer illness duration was associated with lower chance of having tics. Female gender was associated with anxiety, eating and impulse-control disorders. Tic disorders were associated with anxiety disorders and attention-deficit/hyperactivity disorder. No cut-off age at onset was found to clearly divide the sample in homogeneous subgroups. However, cluster analyses revealed that differences started to emerge at the age of 10 and were more pronounced at the age of 17, suggesting that these were the best cut-off points on this sample. Conclusions: Age at onset is associated with specific comorbidity patterns in OCD patients. More prominent differences are obtained when analyzing age at onset as an absolute value. © 2008 Elsevier Masson SAS. All rights reserved.
Issue Date: 
European Psychiatry, v. 23, n. 3, p. 187-194, 2008.
Time Duration: 
  • Age at onset
  • Comorbidity
  • Early onset
  • Late onset
  • Obsessive-compulsive disorder
  • adult
  • age distribution
  • anxiety disorder
  • attention deficit disorder
  • cluster analysis
  • comorbidity
  • diagnostic and statistical manual of mental disorders
  • disease association
  • disease duration
  • eating disorder
  • female
  • human
  • impulse control disorder
  • major clinical study
  • male
  • mental patient
  • obsessive compulsive disorder
  • onset age
  • priority journal
  • psychologic test
  • psychological rating scale
  • regression analysis
  • somatoform disorder
  • structured interview
  • tic
  • Adult
  • Age of Onset
  • Anxiety Disorders
  • Attention Deficit Disorder with Hyperactivity
  • Brazil
  • Cross-Sectional Studies
  • Eating Disorders
  • Female
  • Humans
  • Impulse Control Disorders
  • Male
  • Mental Disorders
  • Middle Aged
  • Obsessive-Compulsive Disorder
  • Personality Assessment
  • Sex Factors
  • Somatoform Disorders
  • Tic Disorders
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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