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Usefulness of Mycobacterium tuberculosis molecular typing in a tuberculosis low-endemic agro-industrial setting of Brazil
  • Universidade Estadual Paulista (UNESP)
  • Universidade Federal do Rio de Janeiro (UFRJ)
  • Instituto Oswaldo Cruz/Fiocruz
  • Américo Brasilienses
  • Institut of Tropical Medicine
To highlight the transmission and major phylogenetic clades of Mycobacterium tuberculosis, a retrospective study was carried out at two health facilities in a small agro-industrial area in São Paulo, Brazil, that has a low tuberculosis incidence rate. IS6110-RFLP and spoligotyping were performed on the isolates, with the former revealing that 31.3% (35/112) of strains were clustered. Epidemiological links were found in 16 of the 35 clustered patients and were associated with transmission among patients living in public housing. Spoligotyping grouped 62.8% of the strains. The T genetic family predominated among the isolates. Of interest is that five strains had a pattern characteristic of African or Asian origin (ST535), and two others were of the rare localized type ST1888 (BRA, VEN). In addition, three new types-1889, 1890, and 1891-were identified. Spoligotyping showed that some ST may be circulating to or from Brazil, and RFLP revealed ongoing transmission in inadequately ventilated public-housing buildings. This may point to a failure in tuberculosis control policy.
Issue Date: 
Japanese Journal of Infectious Diseases, v. 61, n. 3, p. 231-233, 2008.
Time Duration: 
  • pyrazinamide
  • streptomycin
  • Africa
  • Asia
  • bacterial strain
  • bacterial transmission
  • bacterium isolate
  • Brazil
  • community living
  • drug sensitivity
  • geographic origin
  • health care facility
  • human
  • incidence
  • industrial area
  • molecular typing
  • Mycobacterium tuberculosis
  • restriction fragment length polymorphism
  • retrospective study
  • spoligotyping
  • strain identification
  • tuberculosis
  • DNA Transposable Elements
  • Female
  • Humans
  • Incidence
  • Male
  • Oligonucleotides
  • Polymorphism, Restriction Fragment Length
  • Public Housing
  • Tuberculosis, Pulmonary
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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