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- Altered Ex Vivo Expression of Caspase 8, Caspase 9, and Bcl-2 Is Associated with T-Cell Hyporeactivity in Patients with Paracoccidioidomycosis
- Universidade de São Paulo (USP)
- Universidade Estadual Paulista (UNESP)
- Fiocruz MS
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- FAPESP: 02/10893-8
- FAPESP: 02/07306-3
- To better understand the T-cell hyporesponsiveness of patients with paracoccidioidomycosis, we tested the hypothesis that the T cells were committed to apoptosis. We show here that T cells of patients with paracoccidioidomycosis overexpress caspase 9 and caspase 8 but express low Bcl-2 levels and that interleukin-2 was unable to revert the hyporesponsiveness. These data suggest that the T cells would in vivo be driven to a tolerant state and apoptosis.
- Clinical and Vaccine Immunology. Washington: Amer Soc Microbiology, v. 16, n. 6, p. 953-955, 2009.
- Amer Soc Microbiology
- Acesso restrito
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