You are in the accessibility menu

Please use this identifier to cite or link to this item:
Echocardiographic predictors of ventricular remodeling after acute myocardial infarction in rats
Universidade Estadual Paulista (UNESP)
  • 0066-782X
  • 1678-4170
Background: The prediction of the ventricular remodeling process after acute myocardial infarction (AMI) may have important clinical implications. Objetive: To analyze echocardiographic variables predictors of remodeling in the infarction model in rats. Methods: The animals underwent echocardiography in two moments, five days and three months after infarction (AMI group) or sham surgery (control group). Linear regression was used to identify the echocardiographic variables on the fifth day after the infarction, which were predictive of remodeling after three months of coronary occlusion. We considered as a criterion of remodeling in this study, the values of left ventricular diastolic diameter (LVDD) after three months of infarction. Results: The infarction induced increase in the left chambers, associated with changes in systolic and diastolic functions. The variables body weight, left ventricular wall stress index (LVWSI), systolic area (SA), diastolic area (DA), LVDD, left ventricular systolic diameter (LVSD), fractional area change (FAC), ejection fraction (EF), fractional shortening (%Short), posterior wall shortening velocity (PWSV) and infarct size assessed five days after infarction were predictors of LVDD after three months. At the multivariate regression analysis, we included the size of infarction, the LVWSI and PWSV. The LVWSI (coefficient: 4.402, standard error: 2.221, p = 0.05), but not the size of infarction and PWSV, was a predictor of remodeling after three months of infarction. Conclusion: LVPSI was an independent predictor of remodeling three months after the myocardial infarction and could be included in the clinical stratification after the coronary occlusion.
Issue Date: 
Arquivos Brasileiros de Cardiologia, v. 97, n. 6, p. 502-506, 2011.
Time Duration: 
  • Echocardiography
  • Myocardial infarction
  • Rats
  • Ventricular remodeling
  • acute heart infarction
  • animal cell
  • animal experiment
  • animal model
  • animal tissue
  • body weight
  • controlled study
  • echocardiography
  • heart ejection fraction
  • heart infarction size
  • heart ventricle remodeling
  • male
  • nonhuman
  • rat
  • Animals
  • Disease Models, Animal
  • Male
  • Myocardial Infarction
  • Rats, Wistar
  • Time Factors
  • Ventricular Dysfunction, Left
  • Ventricular Remodeling
Access Rights: 
Acesso aberto
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.