Você está no menu de acessibilidade

Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/7331
Título: 
Pharmacokinetic and safety evaluation of the use of ciprofloxacin on an isoniazid-rifampicin regimen in rabbits
Autor(es): 
Instituição: 
Universidade Estadual Paulista (UNESP)
ISSN: 
0142-2782
Financiador: 
  • Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
  • Instituto Nacional de Ciência e Tecnologia - Inovacao Farmaceutica (INCT-if)
Número do financiamento: 
FAPESP: 08/57029-2
Resumo: 
The combination of isoniazid (INH), rifampicin (RMP) and pyrazinamide (PYR) is used in the treatment of tuberculosis. Although this treatment is effective in most clinical cases, the side-effects and the development of mycobacterium resistance have hindered its success. There is evidence that the combination of INH, RMP and ciprofloxacin (CIPRO) is useful in the treatment of tuberculosis. However, the influence of this drug combination on the hepatotoxicity of INH is unknown. In this study, the safety of combined INH, RMP and CIPRO was evaluated. Male albino rabbits (n?=?20) were divided into four groups and subjected to multiple oral doses for 7?days according to the following treatments: water (group 1); 50?mg/kg INH (group 2); 50?mg/kg INH?+?100?mg/kg RMP (group 3) and 50?mg/kg INH?+?100?mg/kg RMP?+?50?mg/kg CIPRO (group 4). Blood samples were taken before and after treatments for the determination of ALT, AST, ALP and bilirubin to assess hepatotoxicity. For pharmacokinetic analysis, serial blood samples were collected over 24?h on day 7 of treatment. Plasma concentrations of INH and acetylisoniazid (AcINH) were determined by HPLC. Biochemical parameters did not show any statistically significant differences between the groups that received the drug combinations. The pharmacokinetic profile of INH was also similar for both groups of combinations. These findings allow us to infer that the inclusion of CIPRO did not increase the risk of hepatotoxicity when compared with the classic combination of INH and RMP. Copyright (C) 2012 John Wiley & Sons, Ltd.
Data de publicação: 
1-Dez-2012
Citação: 
Biopharmaceutics & Drug Disposition. Hoboken: Wiley-blackwell, v. 33, n. 9, p. 501-509, 2012.
Duração: 
501-509
Publicador: 
Wiley-Blackwell
Palavras-chaves: 
  • ciprofloxacin
  • isoniazid
  • preclinical pharmacokinetics
  • hepatotoxicity
  • tuberculosis
Fonte: 
http://dx.doi.org/10.1002/bdd.1817
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/7331
Aparece nas coleções:Artigos, TCCs, Teses e Dissertações da Unesp

Não há nenhum arquivo associado com este item.
 

Itens do Acervo digital da UNESP são protegidos por direitos autorais reservados a menos que seja expresso o contrário.