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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/7364
Título: 
Upregulation of soluble and membrane-bound human leukocyte antigen G expression is primarily observed in the milder histopathological stages of chronic hepatitis C virus infection
Autor(es): 
Instituição: 
  • Universidade Federal do Rio Grande do Norte (UFRN)
  • Universidade Estadual Paulista (UNESP)
  • Univ Fed Mato Grosso
  • Universidade de São Paulo (USP)
  • Univ Paris 07
ISSN: 
0198-8859
Resumo: 
Chronic hepatitis C virus (HCV) infection is a worldwide health problem that may evolve to cirrhosis and hepatocellular carcinoma. Incompletely understood immune system mechanisms have been associated with impaired viral clearance. The nonclassical class I human leukocyte antigen G (HLA-G) molecule may downregulate immune system cell functions exhibiting well-recognized tolerogenic properties. HCV genotype was analyzed in chronic HCV-infected patients. Because HLA-G expression may be induced by certain viruses, we evaluated the presence of HLA-G in the liver microenvironment obtained from 89 biopsies of patients harboring chronic HCV infection and stratified according to clinical and histopathological features. Overall, data indicated that HCV genotype 1 was predominant, especially subgenotype 1a, with a prevalence of 87%. HLA-G expression was observed in 45(51%) liver specimens, and it was more frequent in milder stages of chronic hepatitis (67.4%) than in moderate (27.8%; p = 0.009) and severe (36.0%; p = 0.021) stages of the disease. Altogether, these results suggest that the expression of HLA-G in the context of HCV is a complex process modulated by many factors, which may contribute to an immunologic environment favoring viral persistence. However, because the milder forms predominantly expressed HLA-G, a protective role of this molecule may not be excluded. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier B.V. All rights reserved.
Data de publicação: 
1-Mar-2012
Citação: 
Human Immunology. New York: Elsevier B.V., v. 73, n. 3, p. 258-262, 2012.
Duração: 
258-262
Publicador: 
Elsevier B.V.
Palavras-chaves: 
  • Chronic hepatitis C
  • HLA-G
  • Iron deposit
  • Immunohistochemistry
Fonte: 
http://dx.doi.org/10.1016/j.humimm.2011.12.004
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/7364
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