You are in the accessibility menu

Please use this identifier to cite or link to this item:
Possible mechanism by which zinc protects the testicular function of rats exposed to cigarette smoke
Universidade Estadual Paulista (UNESP)
Background: The aim of this study was to evaluate the changes in testicular function of rats due to cigarette smoke exposure and the possible mechanism by which zinc protects against these alterations. Methods: MaleWistar rats (60 days old) were randomly divided into 3 groups: control (G1, n = 10); exposed to cigarette smoke (G2, n = 10; 20 cigarettes/day/9 weeks) and exposed to cigarette smoke and supplemented with zinc (G3, n = 8; 20 cigarettes/day/9 weeks; 20 mg/kg zinc chloride daily for 9 weeks, by gavage). After the treatment period, the animals were euthanized, and materials were collected for analyses. Results: G2 rats showed a reduction in body mass; impaired sperm concentration, motility, morphology and vitality; and increased malonaldehyde and thiol group levels and superoxide dismutase activity as compared to G1. Zinc prevented the reduction of sperm concentration and the excessive increase of lipid peroxidation and induced an increase in plasma testosterone levels, wet weight of testis and thiol group concentration. Conclusions: Exposure to cigarette smoke led to harmful effects on testicular function at least partially due to the exacerbation of oxidative stress. Supplementary zinc had an important modulator/protector effect on certain parameters. The mechanism of zinc protection can be through an increase of SH concentration. Thus, zinc supplementation may be a promising addition to conventional treatments for male infertility related to smoking. Copyright © 2012 by Institute of Pharmacology Polish Academy of Sciences.
Issue Date: 
Pharmacological Reports, v. 64, n. 6, p. 1537-1546, 2012.
Time Duration: 
  • Oxidative stress
  • Rats
  • Semen
  • Smoking
  • Spermatozoa
  • Testis
  • Zinc
  • cigarette smoke
  • lipid
  • malonaldehyde
  • superoxide dismutase
  • testosterone
  • thiol group
  • zinc chloride
  • animal cell
  • animal experiment
  • animal tissue
  • cell structure
  • controlled study
  • drug mechanism
  • environmental exposure
  • enzyme activity
  • enzyme blood level
  • histopathology
  • hormone determination
  • lipid peroxidation
  • male
  • molecular mechanics
  • nonhuman
  • oxidative stress
  • protein blood level
  • rat
  • semen analysis
  • spermatozoon abnormality
  • spermatozoon density
  • spermatozoon motility
  • testis function
  • testis weight
  • testosterone blood level
  • treatment duration
  • treatment response
  • vitamin supplementation
Access Rights: 
Acesso aberto
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.