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- Anti-Mycobacterium tuberculosis activity of fungus Phomopsis stipata
- Universidade Estadual Paulista (UNESP)
- Faculdades Integradas Pitágoras
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- FAPESP: 11/11593-7
- FAPESP: 08/10390-2
- FAPESP: 06/50680
- FAPESP: 09/06499-1
- Our purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties.
- Brazilian Journal of Microbiology. Sociedade Brasileira de Microbiologia, v. 43, n. 1, p. 224-229, 2012.
- Sociedade Brasileira de Microbiologia
- Phomopsis stipata
- antimycobacterial activity
- Mycobacterium tuberculosis
- Acesso aberto
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