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Photodynamic therapy for the treatment of induced mammary tumor in rats
  • Universidade Estadual Paulista (UNESP)
  • Universidade Do Vale Do Paraíba (UNIVAP)
  • Universidade de São Paulo (USP)
  • 0268-8921
  • 1435-604X
The objective of this work was to evaluate photodynamic therapy (PDT) by using a hematoporphyrin derivative as a photosensitizer and light-emitting diodes (LEDs) as light source in induced mammary tumors of Sprague-Dawley (SD) rats. Twenty SD rats with mammary tumors induced by DMBA were used. Animals were divided into four groups: control (G1), PDT only (G2), surgical removal of tumor (G3), and submitted to PDT immediately after surgical removal of tumor (G4). Tumors were measured over 6 weeks. Lesions and surgical were LEDs lighted up (200 J/cm2 dose). The light distribution in vivo study used two additional animals without mammary tumors. In the control group, the average growth of tumor diameter was approximately 0.40 cm/week. While for PDT group, a growth of less than 0.15 cm/week was observed, suggesting significant delay in tumor growth. Therefore, only partial irradiation of the tumors occurred with a reduction in development, but without elimination. Animals in G4 had no tumor recurrence during the 12 weeks, after chemical induction, when compared with G3 animals that showed 60 % recurrence rate after 12 weeks of chemical induction. PDT used in the experimental model of mammary tumor as a single therapy was effective in reducing tumor development, so the surgery associated with PDT is a safe and efficient destruction of residual tumor, preventing recurrence of the tumor. © 2012 Springer-Verlag London Ltd.
Issue Date: 
Lasers in Medical Science, v. 28, n. 2, p. 571-577, 2013.
Time Duration: 
  • Adjuvant therapy
  • Comet assay
  • Mammary tumors
  • PDT
  • hematoporphyrin derivative
  • photogem
  • unclassified drug
  • animal experiment
  • animal model
  • animal tissue
  • breast surgery
  • breast tumor
  • controlled study
  • drug efficacy
  • female
  • in vivo study
  • light emitting diode
  • nonhuman
  • photodynamic therapy
  • priority journal
  • rat
  • recurrence risk
  • tumor growth
  • tumor recurrence
  • tumor volume
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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