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Evaluation of the bone healing process utilizing platelet-rich plasma activated by thrombin and calcium chloride: A histologic study in rabbit calvaria
  • Universidade Estadual Paulista (UNESP)
  • Universidade Federal de Uberlândia (UFU)
  • 0160-6972
  • 1548-1336
To evaluate the bone healing of defects filled with particulate bone graft in combination with platelet-rich plasma (PRP), added with a mixture of calcium chloride and thrombin or just calcium chloride. Two 5-mm bone defects were created in the calvaria of 24 rabbits. Each defect was filled with particulate bone graft and PRP. In one defect the PRP was activated by a mixture of calcium chloride and thrombin; in the other, PRP was activated by calcium chloride only. The animals were euthanized 1, 2, 4, and 8 weeks after the surgeries, and the calvaria was submitted to histologic processing for histomorphometric analysis. The qualitative analysis has shown that both defects presented the same histologic characteristics so that a better organized, more mature, and well-vascularized bone tissue was noticed in the eighth week. A good bone repair was achieved using either the mixture of calcium chloride and thrombin or the calcium chloride alone as a restarting agent of the coagulation process.
Issue Date: 
Journal of Oral Implantology, v. 39, n. 1, p. 14-21, 2013.
Time Duration: 
  • Bone graft
  • Dental implants
  • Growth factors
  • Platelet-rich plasma
  • calcium chloride
  • thrombin
  • animal
  • blood clotting
  • bone regeneration
  • drug effect
  • evaluation
  • rabbit
  • skull
  • thrombocyte rich plasma
  • Animals
  • Blood Coagulation
  • Bone Regeneration
  • Calcium Chloride
  • Platelet-Rich Plasma
  • Rabbits
  • Skull
  • Thrombin
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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