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Guided implant surgery: What is the influence of this new technique on bone cell viability?
  • Universidade Estadual Paulista (UNESP)
  • University Center of Araraquara-UNIARA
  • 0278-2391
  • 1531-5053
Purpose: To evaluate the effect of implant osteotomy on immediate bone cell viability, comparing guided surgery for implant placement with the classic drilling procedure. Materials and Methods: For this study, 20 rabbits were used. The animals were divided into a guided surgery group (GG) and a control group (CG) and were then divided into 4 subgroups - subgroups 1, 2, 3, and 4 - corresponding to drills used 10, 20, 30, and 40 times, respectively. All animals received 5 osteotomies in each tibia, by use of the classic drilling procedure in one tibia and guided surgery in the other tibia. The osteotomized areas were removed and processed immunohistochemically for detection of osteocalcin, receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), and caspase 3. Results: Immunohistochemical analysis showed that osteocalcin expression was initially higher in the CG and remained constant after drill reutilization. Although the expressions of RANKL and OPG were not statistically different for the GG and CG, the RANKL/OPG ratio tended to be higher for the GG. Moreover, caspase 3 expression was elevated in the GG, proportionally to the number of osteotomies, indicating an increase in the apoptosis index in the GG. Conclusions: The classic drilling procedure is more favorable to cell viability than guided surgery.© 2013 American Association of Oral and Maxillofacial Surgeons.
Issue Date: 
Journal of Oral and Maxillofacial Surgery, v. 71, n. 3, p. 505-512, 2013.
Time Duration: 
  • caspase 3
  • osteocalcin
  • osteoclast differentiation factor
  • osteoprotegerin
  • animal cell
  • animal experiment
  • apoptosis
  • bone cell
  • bone implant
  • bone matrix
  • bone tissue
  • cell viability
  • controlled study
  • cortical bone
  • drilling procedure
  • guided implant surgery
  • immunohistochemistry
  • nonhuman
  • osteocyte
  • protein expression
  • surgical technique
  • tibia osteotomy
  • Animals
  • Bone and Bones
  • Caspase 3
  • Cell Survival
  • Dental Implantation, Endosseous
  • Hot Temperature
  • Male
  • Models, Anatomic
  • Osteocalcin
  • Osteoprotegerin
  • Rabbits
  • RANK Ligand
  • Surgery, Computer-Assisted
  • Tibia
  • Tomography, X-Ray Computed
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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