You are in the accessibility menu

Please use this identifier to cite or link to this item:
Atrophic gastritis: Risk factor for esophageal squamous cell carcinoma in a Latin-American population
  • Cancer Hospital of Barretos
  • Universidade Estadual Paulista (UNESP)
  • 1007-9327
  • 2219-2840
AIM: To study the association between atrophic gastritis (AG) and esophageal squamous cell carcinoma (ESCC) in a Latin-America population. METHODS: A case-control study was performed at two reference Brazilian hospitals including patients diagnosed with advanced ESCC and dyspeptic patients who had been subjected to upper gastrointestinal endoscopy, with biopsies of the gastric antrum and body. All cases with ESCC were reviewed by a single pathologist, who applied standard criteria for the diagnosis of mucosal atrophy, intestinal metaplasia, and dysplasia, all classified as AG. The data on the patients' age, sex, smoking status, and alcohol consumption were collected from clinical records, and any missing information was completed by telephone interview. The association between AG and ESCC was assessed by means of univariate and multiple conditional logistic regressions. RESULTS: Most patients were male, and the median age was 59 years (range: 37-79 years) in both the ESCC and control groups. Univariate analysis showed that an intake of ethanol greater than 32 g/d was an independent risk factor that increased the odds of ESCC 7.57 times (P = 0.014); upon multiple analysis, alcohol intake of ethanol greater than 32 g/d exhibited a risk of 4.54 (P = 0.081), as adjusted for AG and smoking. Smoking was shown to be an independent risk factor that increased the odds of ESCC 14.55 times (P = 0.011) for individuals who smoked 0 to 51 packs/year and 21.40 times (P = 0.006) for those who smoked more than 51 packs/year. Upon multiple analyses, those who smoked up to 51 packs/year exhibited a risk of 7.85 (P = 0.058), and those who smoked more than 51 packs/year had a risk 11.57 times higher (P = 0.04), as adjusted for AG and alcohol consumption. AG proved to be a risk factor that increased the odds of ESCC 5.33 times (95%CI: 1.55-18.30, P = 0.008) according to the results of univariate conditional logistic regression. CONCLUSION: There was an association by univariate conditional logistic regression between AG and ECSS in this sample of Latin-American population. © 2013 Baishideng.
Issue Date: 
World Journal of Gastroenterology, v. 19, n. 13, p. 2060-2064, 2013.
Time Duration: 
  • Alcohol
  • Atrophic gastritis
  • Esophagus
  • Risk factor
  • Squamous cell carcinoma
  • Tobacco
  • adult
  • aged
  • atrophic gastritis
  • case control study
  • controlled study
  • disease association
  • esophageal squamous cell carcinoma
  • female
  • gastrointestinal endoscopy
  • histopathology
  • human
  • human tissue
  • logistic regression analysis
  • male
  • multivariate logistic regression analysis
  • review
  • risk factor
  • South and Central America
Access Rights: 
Acesso aberto
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.