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Bone apposition to laminin-1 coated implants: Histologic and 3D evaluation
  • Malmö University
  • University of Ghent
  • College of Dentistry
  • Kanagawa Dental College
  • Universidade Estadual Paulista (UNESP)
  • New York University
  • Swerea IVF AB
  • Graduate School of Biomedical Sciences
  • 0901-5027
  • 1399-0020
Laminin-1 has been reported as one of the factors responsible for the nucleation of calcium phosphates and, in vitro, has been reported to selectively recruit osteoprogenitors. This article focused on its in vivo effects, and evaluated the effect of laminin-1 local application on osseointegration. Polished cylindrical hydroxyapatite implants were coated with laminin-1 (test) and the bone responses in the rabbit tibiae after 2 and 4 weeks were evaluated and compared to the non-coated implants (control). Before the samples were processed for histological sectioning, they were three-dimensionally analysed with micro computed tomography (μCT). Both evaluation methods were analysed with regards to bone area around the implant and bone to implant contact. From the histologic observation, new bone formation around the laminin-1 coated implant at 2 weeks seemed to have increased the amount of supporting bone around the implant, however, at 4 weeks, the two groups presented no notable differences. The two-dimensional and three-dimensional morphometric evaluation revealed that both histologic and three-dimensional analysis showed some tendency in favour of the test group implants, however there was no statistical significance between the test and control group results. © 2012 International Association of Oral and Maxillofacial Surgeons.
Issue Date: 
International Journal of Oral and Maxillofacial Surgery, v. 42, n. 5, p. 677-682, 2013.
Time Duration: 
  • animal experiments
  • bone implant interactions
  • laminin
  • micro CT
  • hydroxyapatite
  • laminin 1
  • animal experiment
  • animal model
  • animal tissue
  • bone implant
  • bone regeneration
  • computed tomography scanner
  • controlled study
  • ellipsometry
  • histopathology
  • in vivo study
  • material coating
  • micro-computed tomography
  • morphometrics
  • nonhuman
  • ossification
  • rabbit
  • three dimensional imaging
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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