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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/75426
Título: 
Effect of dialysate sodium reduction on body water volume, blood pressure, and inflammatory markers in hemodialysis patients - A prospective randomized controlled study
Autor(es): 
Instituição: 
Universidade Estadual Paulista (UNESP)
ISSN: 
  • 0886-022X
  • 1525-6049
Resumo: 
Accumulating evidence suggests an association between body volume overload and inflammation in chronic kidney diseases. The purpose of this study was to evaluate the effect of dialysate sodium concentration reduction on extracellular water volume, blood pressure (BP), and inflammatory state in hemodialysis (HD) patients. In this prospective controlled study, adult patients on HD for at least 90 days and those with C-reactive protein (CRP) levels ≥ 0.7 mg/dL were randomly allocated into two groups: group A, which included 29 patients treated with reduction of dialysate sodium concentration from 138 to 135 mEq/L; and group B, which included 23 HD patients not receiving dialysate sodium reduction (controls). Of these, 20 patients in group A and 18 in group B completed the protocol study. Inflammatory, biochemical, hematological, and nutritional markers were assessed at baseline and after 8 and 16 weeks. Baseline characteristics were not significantly different between the two groups. Group A showed a significant reduction in serum concentrations of tumor necrosis factor-α, and interleukin-6 over the study period, while the BP and extracellular water (ECW) did not change. In Group B, there were no changes in serum concentrations of inflammatory markers, BP, and ECW. Dialysate sodium reduction is associated with attenuation of the inflammatory state, without changes in the BP and ECW, suggesting inhibition of a salt-induced inflammatory response. Copyright © 2013 Informa Healthcare USA, Inc.
Data de publicação: 
22-Mai-2013
Citação: 
Renal Failure, v. 35, n. 5, p. 742-747, 2013.
Duração: 
742-747
Palavras-chaves: 
  • Blood pressure
  • Body water volume
  • Dialysate sodium
  • Hemodialysis
  • Inflammation
  • Sodium
  • C reactive protein
  • dialysate sodium
  • dialysis fluid
  • interleukin 6
  • tumor necrosis factor alpha
  • unclassified drug
  • adult
  • aged
  • blood pressure
  • body water
  • clinical article
  • controlled study
  • extracellular fluid
  • extracellular space
  • female
  • hemodialysis patient
  • human
  • inflammation
  • male
  • priority journal
  • prospective study
  • protein blood level
  • randomized controlled trial
Fonte: 
http://dx.doi.org/10.3109/0886022X.2013.789961
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/75426
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