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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/7566
Título: 
Determination of gatifloxacin in bulk and tablet preparations by high-performance liquid chromatography
Autor(es): 
Instituição: 
Universidade Estadual Paulista (UNESP)
ISSN: 
1060-3271
Resumo: 
A sensitive, precise, and specific high-performance liquid chromatographic (HPLC) method was developed for the assay of gatifloxacin (GATX) in raw material and tablets. The method validation parameters yielded good results and included the range, linearity, precision, accuracy, specificity, and recovery. It was also found that the excipients in the commercial tablet preparation did not interfere with the assay. The HPLC separation was carried out by reversed-phase chromatography on a C18 absorbosphere column (250 x 4.6 mm id, 5 pm particle size) with a mobile phase composed of acetic acid 50/o--acetonitrile-methanol (70 + 15 + 15, v/v/v) pumped isocratically at a flow rate of 1.0 mL/min. The effluent was monitored at 287 nm. The calibration graph for GATX was linear from 4.0 to 14.0 mu g/mL. The interday and intraday precisions (relative standard deviation) were less than 1.05%.
Data de publicação: 
1-Mai-2006
Citação: 
Journal of Aoac International. Gaithersburg: Aoac International, v. 89, n. 3, p. 642-645, 2006.
Duração: 
642-645
Publicador: 
Aoac International
Fonte: 
http://www.ingentaconnect.com/content/aoac/jaoac/2006/00000089/00000003/art00007
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/7566
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