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Macrophage activity and histopathology of the lymphohematopoietic organs in male Wistar rats orally exposed to single or mixed pesticides
Universidade Estadual Paulista (UNESP)
  • 0360-1234
  • 1532-4109
The noxious effects of low or effective dose exposure to single or mixed pesticides on macrophage activity and the lymphohematopoietic organs were investigated. Male Wistar rats were orally exposed to dichlorvos, dicofol, endosulfan, dieldrin and permethrin, either as single or combined mixtures during a 28-day study containing eight groups: one group received a semipurified diet (non-treated); two groups received a semipurified diet containing low dose mixture (dieldrin 0.025 mg/kg, endosulfan, 0.6 mg/kg, dicofol 0.22 mg/kg, dichlorvos 0.23 mg/kg, permethrin 5 mg/kg) or an effective dose mixture (dichlorvos 2.3 mg/kg, dicofol 2.5 mg/kg, endosulfan 2.9 mg/kg, dieldrin 0.05 mg/kg and permethrin 25.0 mg/kg), respectively; the other five groups received a semipurified diet containing each single pesticide in effective doses. At sacrifice, the thymus, spleen, mesenteric lymph nodes, Payer's patches and bone marrow were removed for histological analysis. Peritoneal macrophages were obtained to determine the phagocytosis and spreading indexes and tumoral necrosis factor alpha (TNF-α), nitric oxide (NO) and H2O2 production. Exposure to pesticide mixtures did not alter the percentage of macrophage phagocytosis and spreading, TNF-α production or the NO and H2O2 release when compared to the non-treated group. Neither was there any apparent evidence that a pesticide mixture at low or effective doses altered the histological structure of the lymphohematopoietic organs. The findings indicate that short-term treatment with pesticide mixtures did not induce an apparent immunotoxic effect in male Wistar rats. © 2013 Copyright Taylor and Francis Group, LLC.
Issue Date: 
Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural Wastes, v. 48, n. 7, p. 607-613, 2013.
Time Duration: 
  • Immunotoxicity
  • lymphohematopoietic organs
  • macrophage activity
  • male rats
  • pesticide mixture
  • Histological analysis
  • Histological structure
  • Male rats
  • Necrosis factors
  • Peritoneal macrophage
  • Pesticide mixture
  • Antigen-antibody reactions
  • Chemical contamination
  • Insecticides
  • Macrophages
  • Mixtures
  • Nitric oxide
  • Nutrition
  • Pesticide effects
  • pesticide
  • tumor necrosis factor alpha
  • bone
  • dichlorvos
  • dieldrin
  • endosulfan
  • histopathology
  • male
  • nitric oxide
  • permethrin
  • rodent
  • animal
  • bone marrow
  • cell culture
  • drug effect
  • immunology
  • lymph node
  • lymphoid tissue
  • macrophage
  • macrophage activation
  • rat
  • spleen
  • thymus
  • Wistar rat
  • Animals
  • Bone Marrow
  • Cells, Cultured
  • Lymph Nodes
  • Lymphoid Tissue
  • Macrophage Activation
  • Male
  • Pesticides
  • Rats
  • Rats, Wistar
  • Spleen
  • Thymus Gland
  • Tumor Necrosis Factor-alpha
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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