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Melatonin and ethanol intake exert opposite effects on circulating estradiol and progesterone and differentially regulate sex steroid receptors in the ovaries, oviducts, and uteri of adult rats
  • Universidade Estadual de Campinas (UNICAMP)
  • Universidade Estadual Paulista (UNESP)
  • Universidade Federal de São Carlos (UFSCar)
  • 0890-6238
  • 1873-1708
Chronic ethanol intake is associated with sex hormone disturbances, and it is well known that melatonin plays a key role in regulating several reproductive processes. We report the effects of ethanol intake and melatonin treatment (at doses of 100. μg/100. g. BW/day) on sex hormones and steroid receptors in the ovaries, oviducts and uteri of ethanol-preferring rats. After 150 days of treatment, animals were euthanized, and tissue samples were harvested to evaluate androgen, estrogen, progesterone and melatonin receptor subunits (AR, ER-α and ER-β, PRA, PRB and MT1R, respectively). Melatonin decreased estradiol (E2) and increased progesterone (P4) and 6-sulfatoxymelatonin (6-STM), while an ethanol-melatonin combination reduced both P4 and E2. Ovarian AR was not influenced by either treatment, and oviduct AR was reduced after ethanol-melatonin combination. Oviduct ER-α, ER-β and uterine ER-β were down-regulated by either ethanol or melatonin. Conversely, ovarian PRA and PRB were positively regulated by ethanol and ethanol-melatonin combination, whereas PRA was down-regulated in the uterus and oviduct after ethanol consumption. MT1R was increased in ovaries and uteri of melatonin-treated rats. Ethanol and melatonin exert opposite effects on E2 and P4, and they differentially regulate the expression of sex steroid receptors in female reproductive tissues. © 2013 Elsevier Inc.
Issue Date: 
Reproductive Toxicology, v. 39, p. 40-49.
Time Duration: 
  • Ethanol
  • Female reproductive tissue
  • Melatonin
  • Sex hormone
  • Sex steroid receptor
  • 6 hydroxymelatonin o sulfate
  • alcohol
  • androgen receptor
  • beta actin
  • daidzein
  • estradiol
  • estrogen receptor alpha
  • estrogen receptor beta
  • genistein
  • melatonin
  • melatonin 1 receptor
  • progesterone
  • progesterone receptor A
  • progesterone receptor B
  • alcohol consumption
  • alcoholism
  • animal experiment
  • animal tissue
  • controlled study
  • dietary intake
  • enzyme activity
  • enzyme regulation
  • female
  • nonhuman
  • nutritional assessment
  • ovary
  • oviduct
  • protein expression
  • protein function
  • rat
  • uterus
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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