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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/76150
Título: 
Humoral and cell-mediated immune responses to different doses of attenuated vaccine against avian infectious bronchitis virus
Autor(es): 
Instituição: 
  • Universidade Estadual Paulista (UNESP)
  • Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
  • South Dakota State University
ISSN: 
  • 0882-8245
  • 1557-8976
Resumo: 
The antibody and cellular immune responses against infectious bronchitis virus (IBV) were evaluated at mucosal sites of chickens after immunization with various doses of an attenuated vaccine at 1 day of age. The correlation of these immune responses with protection of tracheal tissues was evaluated after experimental infection of these birds. Significantly reduced tracheal pathologic effects, measured according to ciliostasis and histology lesions, and reduced viral load were observed only in the full-dose vaccinated group at 5 days post-infection (dpi), while incomplete protection was observed for the subdose vaccinated groups. Moreover, birds of vaccinated groups, especially with full dose, developed higher levels of lachrymal IBV-specific IgG and IgA and increased the expression of cell-mediated immunity (CMI) genes, such as gamma interferon (IFNγ), CD8+ T cell marker, and granzyme homolog A more rapidly. In addition, these humoral and cellular immune responses evaluated at mucosal sites correlated significantly with tracheal protection against homologous IBV challenge in a vaccine dose-dependent manner. The results indicate that IgG, IgA and CD8+ T cell responses developed at mucosal sites after IBV vaccination of day-old chicks, could be taken as good correlates of protection against this virus. © 2013, Mary Ann Liebert, Inc.
Data de publicação: 
1-Ago-2013
Citação: 
Viral Immunology, v. 26, n. 4, p. 259-267, 2013.
Duração: 
259-267
Palavras-chaves: 
  • gamma interferon
  • granzyme A
  • immunoglobulin A
  • immunoglobulin G
  • live vaccine
  • animal experiment
  • animal tissue
  • antibody response
  • avian infectious bronchitis
  • Avian infectious bronchitis virus
  • CD8+ T lymphocyte
  • cellular immunity
  • chicken
  • ciliary dyskinesia
  • controlled study
  • correlational study
  • dose response
  • experimental infection
  • gene expression
  • histopathology
  • humoral immunity
  • infection prevention
  • lacrimal gland
  • nonhuman
  • nucleotide sequence
  • trachea
  • vaccination
  • virus load
Fonte: 
http://dx.doi.org/10.1089/vim.2013.0015
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/76150
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