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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/76293
Título: 
Antioxidant effects of quercetin and naringenin are associated with impaired neutrophil microbicidal activity
Autor(es): 
Instituição: 
  • Universidade Estadual de Maringá (UEM)
  • Universidade Estadual Paulista (UNESP)
ISSN: 
  • 1741-427X
  • 1741-4288
Resumo: 
Naringenin and quercetin are considered antioxidant compounds with promising activity against oxidative damage in human cells. However, no reports have described their effects on reactive oxygen species (ROS) production by phagocytes during microbicidal activity. Thus, the present study evaluated the effects of naringenin and quercetin on ROS production, specifically hypochlorous acid (HOCl), and their involvement in the microbicidal activity of neutrophils. Naringenin and quercetin inhibited HOCl production through different systems, but this inhibition was more pronounced for quercetin, even in the cell-free systems. With regard to the microbicidal activity of neutrophils, both naringenin and quercetin completely inhibited the killing of Staphylococcus aureus. Altogether, these data indicate that the decrease in the oxidant activity of neutrophils induced by these compounds directly impaired the microbicidal activity of neutrophils. Naringenin and quercetin exerted their effects by controlling the effector mechanisms of ROS production, with both positive and negative effects of these antioxidant agents in oxidative stress conditions and on ROS in the microbicidal activity of phagocytes. The present results challenge the traditional view of antioxidants as improvers of pathological conditions. © 2013 Francielli de Cássia Yukari Nishimura et al.
Data de publicação: 
20-Ago-2013
Citação: 
Evidence-based Complementary and Alternative Medicine, v. 2013.
Palavras-chaves: 
  • hypochlorous acid
  • naringenin
  • quercetin
  • reactive oxygen metabolite
  • antioxidant activity
  • controlled study
  • flow cytometry
  • human
  • human cell
  • in vitro study
  • microbial activity
  • neutrophil
  • phagocyte
  • priority journal
  • scanning electron microscopy
  • Staphylococcus aureus
Fonte: 
http://dx.doi.org/10.1155/2013/795916
Endereço permanente: 
Direitos de acesso: 
Acesso aberto
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/76293
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