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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/76472
Título: 
Orthodontic force increases interleukin-1β and tumor necrosis factor-α expression and alveolar bone loss in periodontitis
Autor(es): 
Instituição: 
  • Universidade Estadual Paulista (UNESP)
  • University of Santo Amaro
  • Universidade de São Paulo (USP)
ISSN: 
0022-3492
Resumo: 
Background: The present study aims to evaluate the effects of orthodontic movement (OM) on the periodontal tissues of rats with ligature-induced periodontal disease. Methods: Eighty-eight rats were divided into four groups: 1) negative control (sham operated); 2) periodontal disease; 3) OM; and 4) periodontal disease followed by OM (OMP). Rats were sacrificed 3 hours or 1, 3, or 7 days after OM commencement. Bone volume fraction (BVF) and bone mineral density (BMD) were assessed in hemimaxillae by microcomputed tomography analysis. Expression of the proinflammatory cytokines interleukin (IL)-1β and tumor necrosis factor (TNF)-α were evaluated in gingival samples by quantitative polymerase chain reaction and enzyme-linked immunosorbent assay, and in the furcation region by immunohistochemistry analysis (IHC). Results: The OMP group had lower BVF and BMD levels compared to the other groups at day 7 (P <0.05). Maximum messenger ribonucleic acid expression of both cytokines was observed in the OMP group at day 1 (P <0.05). In the same period, all proteins were expressed in high levels for all test groups compared to the control group. The number of cells positive for IL-1β and TNF-α by IHC was highest in the OMP group at day 1, with progressive reduction thereafter. Conclusion: The results suggest that OM acts synergistically with periodontal disease in periodontal breakdown through upregulation of proinflammatory cytokines.
Data de publicação: 
1-Set-2013
Citação: 
Journal of Periodontology, v. 84, n. 9, p. 1319-1326, 2013.
Duração: 
1319-1326
Palavras-chaves: 
  • Alveolar bone loss
  • Cytokines
  • Interleukin-1
  • Periodontal diseases
  • Tooth movement
  • Tumor necrosis factor-alpha
Fonte: 
http://dx.doi.org/10.1902/jop.2012.120510
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/76472
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