You are in the accessibility menu

Please use this identifier to cite or link to this item:
Neurotoxic action of permethrin in Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae) female ticks. Morphological and cytochemical evaluation of the central nervous system
Universidade Estadual Paulista (UNESP)
  • 0304-4017
  • 1873-2550
Studies on the molecular bases of the neurotoxic action of acaricides are found in the literature; but there are no studies of this action on the nervous system of ticks at the cellular level. The present study describes the morphological and cytochemical changes in the synganglion of Rhipicephalus sanguineus semi-engorged females exposed to different concentrations of permethrin, a pyrethroid with recognized neurotoxic action. Permethrin induced the degeneration of the synganglion through a process of apoptosis involving autophagy, characterized by the condensation and margination of the chromatin, formation of blebs in the nuclear envelope and fragmentation of the nucleus, loss of shape of neural cells and integrity of cellular membrane, cytoplasmic shrinkage, and lower levels of acid phosphatase in the nervous tissue as the concentration of permethrin increased. This study provided further evidence of the neurotoxic action of permethrin, which impairs the metabolism of R. sanguineus nervous systems, and consequently the physiology of other systems, dependent on the neural control. These results provide cytochemical and histological confirmation of the neurotoxic action of permethrin, previously inferred from molecular and tick behavioral evidence. © 2013 Elsevier B.V.
Issue Date: 
Veterinary Parasitology, v. 196, n. 3-4, p. 482-491, 2013.
Time Duration: 
  • Cytotoxicity
  • Degenerative process
  • Pyrethroid
  • Synganglion
  • Ticks
  • acid phosphatase
  • permethrin
  • apoptosis
  • autophagy
  • central nervous system
  • controlled study
  • cytochemistry
  • cytotoxicity
  • ganglion
  • metabolism
  • microbial morphology
  • nerve cell degeneration
  • neurotoxicity
  • nonhuman
  • Rhipicephalus sanguineus
  • Acari
  • Ixodida
  • Ixodidae
Access Rights: 
Acesso aberto
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.