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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/76629
Title: 
Antitumour and anti-inflammatory effects of palladium(II) complexes on Ehrlich tumour
Author(s): 
Institution: 
Universidade Estadual Paulista (UNESP)
ISSN: 
0939-5075
Sponsorship: 
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Abstract: 
Palladium(II) complexes are an important class of cyclopalladated compounds that play a pivotal role in various pharmaceutical applications. Here, we investigated the antitumour, anti-inflammatory, and mutagenic effects of two complexes: [Pd(dmba)(Cl)tu] (1) and [Pd(dmba)(N3)tu] (2) (dmba = N,N-dimethylbenzylamine and tu = thiourea), on Ehrlich ascites tumour (EAT) cells and peritoneal exudate cells (PECs) from mice bearing solid Ehrlich tumour. The cytotoxic effects of the complexes on EAT cells and PECs were assessed using the 3-(4,5-dimethylthiazol-3-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. The effects of the complexes on the immune system were assessed based on the production of nitric oxide (NO) (Griess assay) and tumour necrosis factor-α (TNF-α), interleukin-12 (IL-12), and interleukin-10 (IL-10) (ELISA). Finally the mutagenic activity was assessed by the Ames test using the Salmonella typhimurium strain TA 98. Cisplatin was used as a standard. The IC50 ranges for the growth inhibition of EAT cells and PECs were found to be (72.8 ± 3.23) μM and (137.65 ± 0.22) μM for 1 and (39.7 ± 0.30) μM and (146.51 ± 2.67) μM for 2, respectively. The production of NO, IL-12, and TNF-α, but not IL-10, was induced by both complexes and cisplatin. The complexes showed no mutagenicity in vitro, unlike cisplatin, which was mutagenic in the strain. These results indicate that the complexes are not mutagenic and have potential immunological and antitumour activities. These properties make them promising alternatives to cisplatin. © 2013 Verlag der Zeitschrift für Naturforschung, Tübingen.
Issue Date: 
23-Sep-2013
Citation: 
Zeitschrift fur Naturforschung - Section C Journal of Biosciences, v. 68 C, n. 7-8, p. 293-301, 2013.
Time Duration: 
293-301
Keywords: 
  • Ehrlich Tumour
  • Macrophages
  • Mutagenicity
  • Organometallic
Source: 
http://www.znaturforsch.com/ac/v68c/c68c.htm
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/76629
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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