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Would right atrial stretch inhibit sodium intake following GABAA receptor activation in the lateral parabrachial nucleus?
Universidade Estadual Paulista (UNESP)
  • 0304-3940
  • 1872-7972
The knowledge of the mechanisms underlying circulating volume control may be achieved by stretching a balloon placed at the junction of the superior vena cava-right atrial junction (SVC-RAJ). We investigated whether the inflation of a balloon at the SVC-RAJ inhibits the intake of 0.3M NaCl induced by GABAA receptor activation in the lateral parabrachial nucleus (LPBN) in euhydrated and satiated rats. Male Wistar rats (280-300g) with bilateral stainless steel LPBN cannulae and balloons implanted at the SVC-RAJ were used. Bilateral injections of the GABAA receptor agonist muscimol (0.5ηmol/0.2l) in the LPBN with deflated balloons increased intake of 0.3M NaCl (30.1±3.9 vs. saline: 2.2±0.7)ml/210min, n=8) and water (17.7±1.9 vs. saline: 2.9±0.5ml/210min). Conversely, 0.3M NaCl (27.8±2.1ml/210min) and water (22.8±2.3ml/210min) intake were not affected in rats with inflated balloons at the SVC-RAJ. The results show that sodium and water intake induced by muscimol injected into the LPBN was not affected by balloon inflation at the SVC-RAJ. We suggest that the blockade of LPBN neuronal activity with muscimol injections impairs inhibitory mechanisms activated by signals from cardiopulmonary volume receptors determined by balloon inflation. © 2013 The Authors.
Issue Date: 
Neuroscience Letters, v. 553, p. 121-125.
Time Duration: 
  • Cardiopulmonary volume receptors
  • Circulating volume
  • Lateral parabrachial nucleus
  • Right atrial stretch
  • Sodium intake
  • 4 aminobutyric acid A receptor
  • muscimol
  • silastic
  • stainless steel
  • animal experiment
  • balloon catheter
  • balloon embolization
  • fluid intake
  • male
  • microphotography
  • nonhuman
  • parabrachial nucleus
  • priority journal
  • rat
  • sodium intake
  • superior cava vein
Access Rights: 
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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